TY - JOUR
T1 - Evaluation of pliable bioresorbable, elastomeric aortic valve prostheses in sheep during 12 months post implantation
AU - Vis, Annemijn
AU - de Kort, Bente J.
AU - Szymczyk, Wojciech
AU - van Rijswijk, Jan Willem
AU - Dekker, Sylvia
AU - Driessen, Rob
AU - Wijkstra, Niels
AU - Gründeman, Paul F.
AU - Niessen, Hans W. M.
AU - Janssen, Henk M.
AU - Söntjens, Serge H. M.
AU - Dankers, Patricia Y. W.
AU - Smits, Anthal I. P. M.
AU - Bouten, Carlijn V. C.
AU - Kluin, Jolanda
N1 - Funding Information: We are very grateful to Linda Grutterink and Mariella Volkers for taking and reporting the ultrasound measurements and to Bas van Klarenbosch for taking an emergency ultrasound examination on a very short notice. We thank Onno de Boer, Eva Landman and Neeltje van der Veen for their assistance with the histological analysis and data acquisition. We thank Andras Durko and Marcelle Uiterwijk for their help and expertise. We thank the veterinarians, perfusionists, biotechnicians and animal caretakers for their work and dedication involving the animal experiments. The author’s work is funded by Cardiovascular Onderzoek Nederland grant #CVON2012-01 1Valve, the Gravitation Program “Materials Driven Regeneration,” funded by the Netherlands Organization for Scientific Research, grant # 024.003.013 and by the HybridHeart project, funded by the European Union Horizon 2020 research and innovation programme under grant agreement #767195. Publisher Copyright: © 2023, The Author(s).
PY - 2023/12/1
Y1 - 2023/12/1
N2 - Pliable microfibrous, bioresorbable elastomeric heart valve prostheses are investigated in search of sustainable heart valve replacement. These cell-free implants recruit cells and trigger tissue formation on the valves in situ. Our aim is to investigate the behaviour of these heart valve prostheses when exposed to the high-pressure circulation. We conducted a 12-month follow-up study in sheep to evaluate the in vivo functionality and neo-tissue formation of these valves in the aortic position. All valves remained free from endocarditis, thrombotic complications and macroscopic calcifications. Cell colonisation in the leaflets was mainly restricted to the hinge area, while resorption of synthetic fibers was limited. Most valves were pliable and structurally intact (10/15), however, other valves (5/15) showed cusp thickening, retraction or holes in the leaflets. Further research is needed to assess whether in-situ heart valve tissue engineering in the aortic position is possible or whether non-resorbable synthetic pliable prostheses are preferred.
AB - Pliable microfibrous, bioresorbable elastomeric heart valve prostheses are investigated in search of sustainable heart valve replacement. These cell-free implants recruit cells and trigger tissue formation on the valves in situ. Our aim is to investigate the behaviour of these heart valve prostheses when exposed to the high-pressure circulation. We conducted a 12-month follow-up study in sheep to evaluate the in vivo functionality and neo-tissue formation of these valves in the aortic position. All valves remained free from endocarditis, thrombotic complications and macroscopic calcifications. Cell colonisation in the leaflets was mainly restricted to the hinge area, while resorption of synthetic fibers was limited. Most valves were pliable and structurally intact (10/15), however, other valves (5/15) showed cusp thickening, retraction or holes in the leaflets. Further research is needed to assess whether in-situ heart valve tissue engineering in the aortic position is possible or whether non-resorbable synthetic pliable prostheses are preferred.
UR - http://www.scopus.com/inward/record.url?scp=85176444367&partnerID=8YFLogxK
U2 - https://doi.org/10.1038/s42003-023-05533-3
DO - https://doi.org/10.1038/s42003-023-05533-3
M3 - Article
C2 - 37964029
SN - 2399-3642
VL - 6
JO - Communications Biology
JF - Communications Biology
IS - 1
M1 - 1166
ER -