TY - JOUR
T1 - The role of inflammatory markers in Temporomandibular Myalgia
T2 - A systematic review
AU - Farré-Guasch, Elisabet
AU - Aliberas, Jordi Tomàs
AU - Spada, Natalia Felipe
AU - de Vries, Ralph
AU - Schulten, Engelbert A. J. M.
AU - Lobbezoo, Frank
N1 - Funding Information: We thank the librarian Lluís Alvarez Reguera from Universitat Internacional de Catalunya (UIC) for his excellent support on data collection. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. Publisher Copyright: © 2023
PY - 2023/12/1
Y1 - 2023/12/1
N2 - Approximately 10 % of the general population is affected by temporomandibular disorder (TMD) pain. Diagnosis of myogenous TMD pain (i.e., TM myalgia) may be challenging, while an adequate assessment of this pain is crucial to establish an adequate management strategy. We aim to analyze if there is a relation between inflammation and TM myalgia, and if we can identify and measure inflammatory markers in patients suffering from this condition. An electronic literature search was conducted from inception up to July 14 2022 through the databases PubMed, Cochrane Library, Web of Science, and Embase in collaboration with a medical information specialist. Studies on patients with masticatory muscle inflammation and/or pain were included. After a screening procedure, only nine full-text articles met the criteria for inclusion. In the included studies 9–131 patients showed TM myalgia, and presence of inflammation was reported with analysis of interleukines IL-1, IL-6, IL-10, tumor necrosis factor alpha, and prostaglandins from blood, saliva, and extracellular fluid of masseter muscle using microdialysis. Our results contributed to the identification of the relation between inflammation and TM myalgia and established that measurement of inflammatory cytokines may be a valid diagnostic tool, which is an essential step towards finding a better treatment.
AB - Approximately 10 % of the general population is affected by temporomandibular disorder (TMD) pain. Diagnosis of myogenous TMD pain (i.e., TM myalgia) may be challenging, while an adequate assessment of this pain is crucial to establish an adequate management strategy. We aim to analyze if there is a relation between inflammation and TM myalgia, and if we can identify and measure inflammatory markers in patients suffering from this condition. An electronic literature search was conducted from inception up to July 14 2022 through the databases PubMed, Cochrane Library, Web of Science, and Embase in collaboration with a medical information specialist. Studies on patients with masticatory muscle inflammation and/or pain were included. After a screening procedure, only nine full-text articles met the criteria for inclusion. In the included studies 9–131 patients showed TM myalgia, and presence of inflammation was reported with analysis of interleukines IL-1, IL-6, IL-10, tumor necrosis factor alpha, and prostaglandins from blood, saliva, and extracellular fluid of masseter muscle using microdialysis. Our results contributed to the identification of the relation between inflammation and TM myalgia and established that measurement of inflammatory cytokines may be a valid diagnostic tool, which is an essential step towards finding a better treatment.
KW - Cytokines
KW - Inflammation
KW - Muscle
KW - Myogenous
KW - Pain
KW - Temporomandibular
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U2 - https://doi.org/10.1016/j.jdsr.2023.08.006
DO - https://doi.org/10.1016/j.jdsr.2023.08.006
M3 - Review article
C2 - 37680612
SN - 1882-7616
VL - 59
SP - 281
EP - 288
JO - Japanese Dental Science Review
JF - Japanese Dental Science Review
ER -