TY - JOUR
T1 - The Effect of Roux-en-Y Gastric Bypass on Bone Marrow Adipose Tissue and Bone Mineral Density in Postmenopausal, Nondiabetic Women
AU - Beekman, Kerensa M.
AU - Akkerman, Erik M.
AU - Streekstra, Geert J.
AU - Veldhuis-Vlug, Annegreet G.
AU - Acherman, Yair
AU - Gerdes, Victor E.
AU - den Heijer, Martin
AU - Maas, Mario
AU - Bravenboer, Nathalie
AU - Bisschop, Peter H.
N1 - Funding Information: This study has been funded by an Alliance Grant provided by Amsterdam University Medical Center/Amsterdam Movement Sciences (Grant 2013‐01). Funding sources had no influence on the study design, the interpretation of the results, or the manuscript. Publisher Copyright: © 2021 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society (TOS). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/7
Y1 - 2021/7
N2 - Objectives: This study aimed to determine the effect of bariatric surgery-induced weight loss on bone marrow adipose tissue (BMAT) and bone mineral density (BMD) in postmenopausal, nondiabetic women. Methods: A total of 14 postmenopausal, nondiabetic women with obesity who were scheduled for laparoscopic Roux-en-Y gastric bypass surgery (RYGB) were included in this study. Vertebral bone marrow fat signal fraction was determined by quantitative chemical shift magnetic resonance imaging, and vertebral volumetric BMD (vBMD) was determined by quantitative computed tomography before surgery and 3 and 12 months after surgery. Data were analyzed by linear mixed model. Results: Body weight [mean (SD)] decreased after surgery from 108 (13) kg at baseline to 89 (12) kg at 3 months and 74 (11) kg at 12 months (P < 0.001). BMAT decreased after surgery from 51% (8%) at baseline to 50% (8%) at 3 months and 46% (7%) at 12 months (P = 0.004). vBMD decreased after surgery from 101 (26) mg/cm 3 at baseline to 94 (28) mg/cm 3 at 3 months (P = 0.003) and 94 (28) mg/cm 3 at 12 months (P = 0.035). Changes in BMAT and vBMD were not correlated (ρ = −0.10 and P = 0.75). Calcium and vitamin D concentrations did not change after surgery. Conclusions: RYGB decreases both BMAT (after 12 months) and vBMD (both after 3 months and 12 months) in postmenopausal, nondiabetic women. Changes in BMAT and vBMD were not correlated. These findings suggest that BMAT does not contribute to bone loss following RYGB.
AB - Objectives: This study aimed to determine the effect of bariatric surgery-induced weight loss on bone marrow adipose tissue (BMAT) and bone mineral density (BMD) in postmenopausal, nondiabetic women. Methods: A total of 14 postmenopausal, nondiabetic women with obesity who were scheduled for laparoscopic Roux-en-Y gastric bypass surgery (RYGB) were included in this study. Vertebral bone marrow fat signal fraction was determined by quantitative chemical shift magnetic resonance imaging, and vertebral volumetric BMD (vBMD) was determined by quantitative computed tomography before surgery and 3 and 12 months after surgery. Data were analyzed by linear mixed model. Results: Body weight [mean (SD)] decreased after surgery from 108 (13) kg at baseline to 89 (12) kg at 3 months and 74 (11) kg at 12 months (P < 0.001). BMAT decreased after surgery from 51% (8%) at baseline to 50% (8%) at 3 months and 46% (7%) at 12 months (P = 0.004). vBMD decreased after surgery from 101 (26) mg/cm 3 at baseline to 94 (28) mg/cm 3 at 3 months (P = 0.003) and 94 (28) mg/cm 3 at 12 months (P = 0.035). Changes in BMAT and vBMD were not correlated (ρ = −0.10 and P = 0.75). Calcium and vitamin D concentrations did not change after surgery. Conclusions: RYGB decreases both BMAT (after 12 months) and vBMD (both after 3 months and 12 months) in postmenopausal, nondiabetic women. Changes in BMAT and vBMD were not correlated. These findings suggest that BMAT does not contribute to bone loss following RYGB.
UR - http://www.scopus.com/inward/record.url?scp=85105089362&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/oby.23171
DO - https://doi.org/10.1002/oby.23171
M3 - Article
C2 - 33951317
SN - 1930-7381
VL - 29
SP - 1120
EP - 1127
JO - Obesity
JF - Obesity
IS - 7
ER -