Metabolic interventions in chronic lymphocytic leukemia: Towards tumor elimination and immune rejuvenation

C. Montironi

Metabolic interventions in chronic lymphocytic leukemia: Towards tumor elimination and immune rejuvenation

Research output: PhD Thesis › Phd-Thesis - Research and graduation internal

Abstract

Chronic lymphocytic leukemia (CLL), the most common adult leukemia in the Western world, remains incurable despite significant treatment advances. Targeted therapies, such as venetoclax + ibrutinib, directed at killing malignant cells, face the emergence of resistance, due to microenvironmental protective stimuli and genetic mutations (e.g. TP53). T-cell based immunotherapies show

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	University of Amsterdam
Supervisors/Advisors	Eldering, Eric, Supervisor Simon Molas, Helga, Co-supervisor
Award date	16 Feb 2024
Print ISBNs	9789464836097
Publication status	Published - 2024

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title = "Metabolic interventions in chronic lymphocytic leukemia: Towards tumor elimination and immune rejuvenation",

abstract = "Chronic lymphocytic leukemia (CLL), the most common adult leukemia in the Western world, remains incurable despite significant treatment advances. Targeted therapies, such as venetoclax + ibrutinib, directed at killing malignant cells, face the emergence of resistance, due to microenvironmental protective stimuli and genetic mutations (e.g. TP53). T-cell based immunotherapies show",

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type = "Phd-Thesis - Research and graduation internal",

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T2 - Towards tumor elimination and immune rejuvenation

AU - Montironi, C.

PY - 2024

Y1 - 2024

N2 - Chronic lymphocytic leukemia (CLL), the most common adult leukemia in the Western world, remains incurable despite significant treatment advances. Targeted therapies, such as venetoclax + ibrutinib, directed at killing malignant cells, face the emergence of resistance, due to microenvironmental protective stimuli and genetic mutations (e.g. TP53). T-cell based immunotherapies show

AB - Chronic lymphocytic leukemia (CLL), the most common adult leukemia in the Western world, remains incurable despite significant treatment advances. Targeted therapies, such as venetoclax + ibrutinib, directed at killing malignant cells, face the emergence of resistance, due to microenvironmental protective stimuli and genetic mutations (e.g. TP53). T-cell based immunotherapies show

UR - https://pure.uva.nl/ws/files/154657792/Licence_Agreement_co-signed_.pdf

UR - https://pure.uva.nl/ws/files/154657794/Propositions.pdf

M3 - Phd-Thesis - Research and graduation internal

SN - 9789464836097

ER -

Metabolic interventions in chronic lymphocytic leukemia: Towards tumor elimination and immune rejuvenation

Abstract

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