A blended eHealth intervention for insomnia following acquired brain injury: a randomised controlled trial: a randomised controlled trial

M.E Ford, G.J. Geurtsen, E. Groet, R.D. Rambaran Mishre, C.A.M. Van Bennekom, E.J.W. Van Someren

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)


The high prevalence and severe consequences of poor sleep following acquired brain injury emphasises the need for an effective treatment. However, treatment studies are scarce. The present study evaluates the efficacy of blended online cognitive behavioural therapy for insomnia (eCBT-I) developed specifically for people with acquired brain injury. In a multicentre prospective, open-label, blinded end-point randomised clinical trial, 52 participants with insomnia and a history of a stroke or traumatic brain injury were randomised to 6 weeks of guided eCBT-I or treatment as usual, with a 6-week follow-up. The primary outcome measure was the change in insomnia severity between baseline and after treatment, measured with the Insomnia Severity Index. Results showed that insomnia severity improved significantly more with eCBT-I than with treatment as usual compared to baseline, both at post-treatment (mean [SEM] 4.0 [1.3] insomnia severity index points stronger decrease, d = 0.96, p < 0.003) and at follow-up (mean [SEM] 3.2 [1.5] insomnia severity index points, d = -0.78, p < 0.03). In conclusion, our randomised clinical trial shows that blended CBT is an effective treatment for insomnia, and feasible for people with acquired brain injury, regardless of cognitive and psychiatric complaints. Online treatment has major advantages in terms of availability and cost and may contribute to the successful implementation of insomnia treatment for people with acquired brain injuries.

Original languageEnglish
Article numbere13629
Pages (from-to)1-9
Number of pages9
JournalJournal of sleep research
Issue number1
Early online date31 May 2022
Publication statusPublished - Feb 2023


  • Brain Injuries/complications
  • Cognitive Behavioral Therapy/methods
  • Humans
  • Prospective Studies
  • Sleep Initiation and Maintenance Disorders/etiology
  • Telemedicine
  • Treatment Outcome
  • brain injuries
  • cognitive behavioural therapy
  • sleep
  • stroke
  • traumatic

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