A case of silicone and sarcoid granulomas in a patient with “highly cohesive” silicone breast implants: A histopathologic and laser raman microprobe analysis

Todor I. Todorov, Erik de Bakker, Diane Smith, Lisette C. Langenberg, Linda A. Murakata, Mark H. H. Kramer, Jose A. Centeno, Prabath W. B. Nanayakkara

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)


Foreign body giant cell (FBGC) reaction to silicone material in the lymph nodes of patients with silicone breast implants has been documented in the literature, with a number of case reports dating back to 1978. Many of these case reports describe histologic features of silicone lymphadenopa-thy in regional lymph nodes from patients with multiple sets of different types of implants, including single lumen smooth surface gel, single lumen textured surface gel, single lumen with polyethylene terephthalate patch, single lumen with polyurethane coating, and double lumen smooth surface. Only one other case report described a patient with highly-cohesive breast implants and silicone granulomas of the skin. In this article, we describe a patient with a clinical presentation of systemic sarcoidosis following highly cohesive breast implant placement. Histopathologic analysis and Confo-cal Laser Raman Microprobe (CLRM) examination were used to confirm the presence of silicone in the axillary lymph node and capsular tissues. This is the first report where chemical spectroscopic mapping has been used to establish and identify the coexistence of Schaumann bodies, consisting of calcium oxalate and calcium phosphate minerals, together with silicone implant material.
Original languageEnglish
Article number4526
JournalInternational journal of environmental research and public health
Issue number9
Publication statusPublished - 1 May 2021


  • Breast implant
  • Raman
  • Sarcoidosis
  • Schaumann bodies
  • Silicone

Cite this