A comparison of the in vitro cytotoxicity of daunorubicin and liposomal daunorubicin in pediatric acute leukemia

Bianca F. Goemans; Christian M. Zwaan; Dirk Reinhardt; Brenda E.S. Gibson; K. Hählen; Gert Jan L. Kaspers

A comparison of the in vitro cytotoxicity of daunorubicin and liposomal daunorubicin in pediatric acute leukemia

Bianca F. Goemans, Christian M. Zwaan, Dirk Reinhardt, Brenda E.S. Gibson, K. Hählen, Gert Jan L. Kaspers

Pediatric surgery (VUmc)

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Anthracyclines are effective in the treatment of leukemia, but their use is limited because of cardiotoxicity. Liposomal daunorubicin (L-DNR) is potentially less cardiotoxic than daunorubicin (DNR). We compared in vitro cytotoxicity in pediatric acute leukemia samples and found no significant differences between cytotoxicity of DNR and L-DNR.

Original language	English
Pages (from-to)	1573-1574
Number of pages	2
Journal	Haematologica
Volume	91
Issue number	11
Publication status	Published - Nov 2006

Keywords

Cardiotoxicity
Drug sensitivity
Liposomal daunombicin
Pediatric acute leukemia

Cite this

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abstract = "Anthracyclines are effective in the treatment of leukemia, but their use is limited because of cardiotoxicity. Liposomal daunorubicin (L-DNR) is potentially less cardiotoxic than daunorubicin (DNR). We compared in vitro cytotoxicity in pediatric acute leukemia samples and found no significant differences between cytotoxicity of DNR and L-DNR.",

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AU - Goemans, Bianca F.

AU - Zwaan, Christian M.

AU - Reinhardt, Dirk

AU - Gibson, Brenda E.S.

AU - Hählen, K.

AU - Kaspers, Gert Jan L.

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N2 - Anthracyclines are effective in the treatment of leukemia, but their use is limited because of cardiotoxicity. Liposomal daunorubicin (L-DNR) is potentially less cardiotoxic than daunorubicin (DNR). We compared in vitro cytotoxicity in pediatric acute leukemia samples and found no significant differences between cytotoxicity of DNR and L-DNR.

AB - Anthracyclines are effective in the treatment of leukemia, but their use is limited because of cardiotoxicity. Liposomal daunorubicin (L-DNR) is potentially less cardiotoxic than daunorubicin (DNR). We compared in vitro cytotoxicity in pediatric acute leukemia samples and found no significant differences between cytotoxicity of DNR and L-DNR.

KW - Cardiotoxicity

KW - Drug sensitivity

KW - Liposomal daunombicin

KW - Pediatric acute leukemia

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M3 - Article

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SN - 0390-6078

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IS - 11

ER -

A comparison of the in vitro cytotoxicity of daunorubicin and liposomal daunorubicin in pediatric acute leukemia

Abstract

Keywords

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