A deletion in DJ-1 and the risk of dementia - a population-based survey

Alejandro Arias Vásquez; Kristel Sleegers; Marieke C. J. Dekker; Willem A. van Gool; John C. van Swieten; Yurii S. Aulchenko; Ben A. Oostra; Cornelia M. van Duijn

doi:https://doi.org/10.1016/j.neulet.2004.09.040

A deletion in DJ-1 and the risk of dementia - a population-based survey

Alejandro Arias Vásquez, Kristel Sleegers, Marieke C. J. Dekker, Willem A. van Gool, John C. van Swieten, Yurii S. Aulchenko, Ben A. Oostra, Cornelia M. van Duijn

Neurology (AMC)

Research output: Contribution to journal › Article › Academic › peer-review

6 Citations (Scopus)

Abstract

The DJ-1 gene is associated with autosomal recessive early-onset Parkinsonism, most likely through its role in defense against oxidative stress. Oxidative stress is not only involved in Parkinson's disease, but also in other neurodegenerative disorders, such as dementia. We assessed the presence of a 14 kb DJ-1 deletion in 191 patients with dementia, ascertained from the genetically isolated population where the first kindred with DJ-1 related Parkinsonism was originally identified. The control group consisted of 129 non-demented subjects. We found the deletion in two patients and one control. There was no evidence for an increased risk of dementia in carriers. All subjects were heterozygous for the deletion and related to a common ancestor within eight generations. Our results suggest it is unlikely that haploinsufficiency in the DJ-1 gene imparts an increased risk for dementia. (C) 2004 Elsevier Ireland Ltd. All rights reserved

Original language	English
Pages (from-to)	196-199
Journal	Neuroscience letters
Volume	372
Issue number	3
DOIs	https://doi.org/10.1016/j.neulet.2004.09.040
Publication status	Published - 2004

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https://doi.org/10.1016/j.neulet.2004.09.040

Cite this

@article{8b75f0cc6f63455588f139500e253291,

title = "A deletion in DJ-1 and the risk of dementia - a population-based survey",

abstract = "The DJ-1 gene is associated with autosomal recessive early-onset Parkinsonism, most likely through its role in defense against oxidative stress. Oxidative stress is not only involved in Parkinson's disease, but also in other neurodegenerative disorders, such as dementia. We assessed the presence of a 14 kb DJ-1 deletion in 191 patients with dementia, ascertained from the genetically isolated population where the first kindred with DJ-1 related Parkinsonism was originally identified. The control group consisted of 129 non-demented subjects. We found the deletion in two patients and one control. There was no evidence for an increased risk of dementia in carriers. All subjects were heterozygous for the deletion and related to a common ancestor within eight generations. Our results suggest it is unlikely that haploinsufficiency in the DJ-1 gene imparts an increased risk for dementia. (C) 2004 Elsevier Ireland Ltd. All rights reserved",

author = "{Arias V{\'a}squez}, Alejandro and Kristel Sleegers and Dekker, {Marieke C. J.} and {van Gool}, {Willem A.} and {van Swieten}, {John C.} and Aulchenko, {Yurii S.} and Oostra, {Ben A.} and {van Duijn}, {Cornelia M.}",

year = "2004",

doi = "https://doi.org/10.1016/j.neulet.2004.09.040",

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T1 - A deletion in DJ-1 and the risk of dementia - a population-based survey

AU - Arias Vásquez, Alejandro

AU - Sleegers, Kristel

AU - Dekker, Marieke C. J.

AU - van Gool, Willem A.

AU - van Swieten, John C.

AU - Aulchenko, Yurii S.

AU - Oostra, Ben A.

AU - van Duijn, Cornelia M.

PY - 2004

Y1 - 2004

N2 - The DJ-1 gene is associated with autosomal recessive early-onset Parkinsonism, most likely through its role in defense against oxidative stress. Oxidative stress is not only involved in Parkinson's disease, but also in other neurodegenerative disorders, such as dementia. We assessed the presence of a 14 kb DJ-1 deletion in 191 patients with dementia, ascertained from the genetically isolated population where the first kindred with DJ-1 related Parkinsonism was originally identified. The control group consisted of 129 non-demented subjects. We found the deletion in two patients and one control. There was no evidence for an increased risk of dementia in carriers. All subjects were heterozygous for the deletion and related to a common ancestor within eight generations. Our results suggest it is unlikely that haploinsufficiency in the DJ-1 gene imparts an increased risk for dementia. (C) 2004 Elsevier Ireland Ltd. All rights reserved

AB - The DJ-1 gene is associated with autosomal recessive early-onset Parkinsonism, most likely through its role in defense against oxidative stress. Oxidative stress is not only involved in Parkinson's disease, but also in other neurodegenerative disorders, such as dementia. We assessed the presence of a 14 kb DJ-1 deletion in 191 patients with dementia, ascertained from the genetically isolated population where the first kindred with DJ-1 related Parkinsonism was originally identified. The control group consisted of 129 non-demented subjects. We found the deletion in two patients and one control. There was no evidence for an increased risk of dementia in carriers. All subjects were heterozygous for the deletion and related to a common ancestor within eight generations. Our results suggest it is unlikely that haploinsufficiency in the DJ-1 gene imparts an increased risk for dementia. (C) 2004 Elsevier Ireland Ltd. All rights reserved

U2 - https://doi.org/10.1016/j.neulet.2004.09.040

DO - https://doi.org/10.1016/j.neulet.2004.09.040

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