A function for the macrophage F4/80 molecule in tolerance induction

Timo K van den Berg, Georg Kraal

Research output: Contribution to journalReview articleAcademicpeer-review

73 Citations (Scopus)


The F4/80 monoclonal antibody has been used widely as a marker for mouse macrophages. The antigen (Ag) recognized by the antibody has been characterized as a member of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family, although the function of the molecule has remained elusive. A recent study provides evidence for a role of the F4/80 molecule in the induction of immunological tolerance. This study appears to provide clear evidence for a role of the F4/80 molecule in the immune system, however, what does it really tell us about the activities of the F4/80 molecule?

Original languageEnglish
Pages (from-to)506-9
Number of pages4
JournalTrends in immunology
Issue number10
Publication statusPublished - Oct 2005


  • Animals
  • Antibodies, Monoclonal/immunology
  • Antibody Specificity
  • Antigens, Differentiation/physiology
  • Glycoproteins/genetics
  • Immune Tolerance/immunology
  • Macrophages/immunology
  • Mice
  • Models, Immunological

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