A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

A.K. Manning; M.F. Hivert; R.A. Scott; J.L. Grimsby; N. Bouatia-Naji; H. Chen; D. Rybin; C.T. Liu; L.F. Bielak; I. Prokopenko; N. Amin; D. Barnes; G. Cadby; J.J. Hottenga; E. Ingelsson; D.I. Boomsma; E.J.C. de Geus; B.W.J.H. Penninx; G. Willemsen; J.F. Wilson; J.C.M. Witteman; A.F. Wright; H. Yaghootkar; D. Zelenika; T. Zemunik; L. Zgaga; N.J. Wareham; M.I. McCarthy; I. Barroso; R.M. Watanabe; J.C. Florez; J. Dupuis; J.B. Meigs; C. Langenberg

doi:https://doi.org/10.1038/ng.2274

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

A.K. Manning, M.F. Hivert, R.A. Scott, J.L. Grimsby, N. Bouatia-Naji, H. Chen, D. Rybin, C.T. Liu, L.F. Bielak, I. Prokopenko, N. Amin, D. Barnes, G. Cadby, J.J. Hottenga, E. Ingelsson, D.I. Boomsma, E.J.C. de Geus, B.W.J.H. Penninx, G. Willemsen, J.F. WilsonJ.C.M. Witteman, A.F. Wright, H. Yaghootkar, D. Zelenika, T. Zemunik, L. Zgaga, N.J. Wareham, M.I. McCarthy, I. Barroso, R.M. Watanabe, J.C. Florez, J. Dupuis, J.B. Meigs, C. Langenberg

Research output: Contribution to journal › Article › Academic › peer-review

602 Citations (Scopus)

Abstract

Recent genome-wide association studies have described many loci implicated in type 2 diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the understanding of the genetic basis of insulin resistance. We hypothesized that genes implicated in insulin resistance pathways might be uncovered by accounting for differences in body mass index (BMI) and potential interactions between BMI and genetic variants. We applied a joint meta-analysis approach to test associations with fasting insulin and glucose on a genome-wide scale. We present six previously unknown loci associated with fasting insulin at P < 5 × 10

Original language	English
Pages (from-to)	659-669
Journal	Nature Genetics
Volume	44
Issue number	6
DOIs	https://doi.org/10.1038/ng.2274
Publication status	Published - 2012

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https://doi.org/10.1038/ng.2274

Cite this

Manning, A. K., Hivert, M. F., Scott, R. A., Grimsby, J. L., Bouatia-Naji, N., Chen, H., Rybin, D., Liu, C. T., Bielak, L. F., Prokopenko, I., Amin, N., Barnes, D., Cadby, G., Hottenga, J. J., Ingelsson, E., Boomsma, D. I., de Geus, E. J. C., Penninx, B. W. J. H., Willemsen, G., ... Langenberg, C. (2012). A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nature Genetics, 44(6), 659-669. https://doi.org/10.1038/ng.2274

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abstract = "Recent genome-wide association studies have described many loci implicated in type 2 diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the understanding of the genetic basis of insulin resistance. We hypothesized that genes implicated in insulin resistance pathways might be uncovered by accounting for differences in body mass index (BMI) and potential interactions between BMI and genetic variants. We applied a joint meta-analysis approach to test associations with fasting insulin and glucose on a genome-wide scale. We present six previously unknown loci associated with fasting insulin at P < 5 × 10",

author = "A.K. Manning and M.F. Hivert and R.A. Scott and J.L. Grimsby and N. Bouatia-Naji and H. Chen and D. Rybin and C.T. Liu and L.F. Bielak and I. Prokopenko and N. Amin and D. Barnes and G. Cadby and J.J. Hottenga and E. Ingelsson and D.I. Boomsma and {de Geus}, E.J.C. and B.W.J.H. Penninx and G. Willemsen and J.F. Wilson and J.C.M. Witteman and A.F. Wright and H. Yaghootkar and D. Zelenika and T. Zemunik and L. Zgaga and N.J. Wareham and M.I. McCarthy and I. Barroso and R.M. Watanabe and J.C. Florez and J. Dupuis and J.B. Meigs and C. Langenberg",

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doi = "https://doi.org/10.1038/ng.2274",

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Manning, AK, Hivert, MF, Scott, RA, Grimsby, JL, Bouatia-Naji, N, Chen, H, Rybin, D, Liu, CT, Bielak, LF, Prokopenko, I, Amin, N, Barnes, D, Cadby, G, Hottenga, JJ, Ingelsson, E, Boomsma, DI, de Geus, EJC, Penninx, BWJH, Willemsen, G, Wilson, JF, Witteman, JCM, Wright, AF, Yaghootkar, H, Zelenika, D, Zemunik, T, Zgaga, L, Wareham, NJ, McCarthy, MI, Barroso, I, Watanabe, RM, Florez, JC, Dupuis, J, Meigs, JB & Langenberg, C 2012, 'A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance', Nature Genetics, vol. 44, no. 6, pp. 659-669. https://doi.org/10.1038/ng.2274

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T1 - A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

AU - Manning, A.K.

AU - Hivert, M.F.

AU - Scott, R.A.

AU - Grimsby, J.L.

AU - Bouatia-Naji, N.

AU - Chen, H.

AU - Rybin, D.

AU - Liu, C.T.

AU - Bielak, L.F.

AU - Prokopenko, I.

AU - Amin, N.

AU - Barnes, D.

AU - Cadby, G.

AU - Hottenga, J.J.

AU - Ingelsson, E.

AU - Boomsma, D.I.

AU - de Geus, E.J.C.

AU - Penninx, B.W.J.H.

AU - Willemsen, G.

AU - Wilson, J.F.

AU - Witteman, J.C.M.

AU - Wright, A.F.

AU - Yaghootkar, H.

AU - Zelenika, D.

AU - Zemunik, T.

AU - Zgaga, L.

AU - Wareham, N.J.

AU - McCarthy, M.I.

AU - Barroso, I.

AU - Watanabe, R.M.

AU - Florez, J.C.

AU - Dupuis, J.

AU - Meigs, J.B.

AU - Langenberg, C.

PY - 2012

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AB - Recent genome-wide association studies have described many loci implicated in type 2 diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the understanding of the genetic basis of insulin resistance. We hypothesized that genes implicated in insulin resistance pathways might be uncovered by accounting for differences in body mass index (BMI) and potential interactions between BMI and genetic variants. We applied a joint meta-analysis approach to test associations with fasting insulin and glucose on a genome-wide scale. We present six previously unknown loci associated with fasting insulin at P < 5 × 10

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DO - https://doi.org/10.1038/ng.2274

M3 - Article

C2 - 22581228

SN - 1061-4036

VL - 44

SP - 659

EP - 669

JO - Nature Genetics

JF - Nature Genetics

IS - 6

ER -