A Genome-Wide Association Study of Depressive Symptoms

K. Hek, A. Demirkan, J. Lahti, A. Terracciano, A. Teumer, M.C. Cornelis, N. Amin, E. Bakshis, J. Baumert, J. Ding, Y Liu, K. Marciante, O. Meirelles, M.A. Nalls, Y.V. Sun, N. Vogelzangs, L. Yu, S. Bandinelli, E.J. Benjamin, D.A. BennettD.I. Boomsma, A. Cannas, L.H. Coker, E.J.C. de Geus, P.L. Jager, A.V. Diez-Roux, S. Purcell, F.B. Hu, E.B. Rimm, D.J. Hunter, M.K. Jensen, G. Curhan, K. Rice, A.D. Penman, J.I. Rotter, N. Sotoodehnia, R. Emeny, J.G. Eriksson, D.A. Evans, L. Ferrucci, M. Fornage, V. Gudnason, A. Hofman, T. Illig, S. Kardia, M. Kelly-Hayes, K. Koenen, P. Kraft, M. Kuningas, J.M. Massaro, D. Melzer, A. Mulas, C.L. Mulder, A. Murray, B.A. Oostra, A. Palotie, B.W.J.H. Penninx, A. Petersmann, L.C. Pilling, B. Psaty, R. Rawal, E.M. Reiman, A. Schulz, J.M. Shulman, A.B. Singleton, A.V. Smith, A.R. Sutin, A.G. Uitterlinden, H. Völzke, E. Widen, K. Yaffe, A.B. Zonderman, F. Cucca, T. Harris, K.H. Ladwig, D.J. Llewellyn, K. Räikkönen, T. Tanaka, C.M. van Duijn, H.J. Grabe, L.J. Launer, K.L. Lunetta, T.H. Mosley, A.B. Newman, H. Tiemeier, J. Murabito

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Background: Depression is a heritable trait that exists on a continuum of varying severity and duration. Yet, the search for genetic variants associated with depression has had few successes. We exploit the entire continuum of depression to find common variants for depressive symptoms. Methods: In this genome-wide association study, we combined the results of 17 population-based studies assessing depressive symptoms with the Center for Epidemiological Studies Depression Scale. Replication of the independent top hits (p<1×10
Original languageEnglish
Pages (from-to)667-678
JournalBiological Psychiatry
Issue number7
Publication statusPublished - 2013

Cohort Studies

  • Netherlands Twin Register (NTR)

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