A lethal case of the dapsone hypersensitivity syndrome involving the myocardium

R. M. Hoogeveen; T. van der Bom; H. H. de Boer; R. M. Thurlings; B. S. Wind; H. J. C. de Vries; A. U. van Lent; U. Beuers; A. C. van der Wal; F. J. Nellen

A lethal case of the dapsone hypersensitivity syndrome involving the myocardium

R. M. Hoogeveen, T. van der Bom, H. H. de Boer, R. M. Thurlings, B. S. Wind, H. J. C. de Vries, A. U. van Lent, U. Beuers, A. C. van der Wal, F. J. Nellen

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14 Citations (Scopus)

Abstract

In the Netherlands dapsone is used for the treatment of dermatitis herpetiformis, leprosy and Pneumocystis jiroveci pneumonia and prophylaxis in case of cotrimoxazole allergy. An idiosyncratic drug reaction, known as the dapsone hypersensitivity syndrome (DHS), appears in about 0.5-3.6% of persons treated with dapsone. DHS can be associated with fever, rash and systemic involvement. We present a 35-year-old woman who developed severe DHS seven weeks after starting dapsone. Six weeks after being discharged in a good clinical condition she died from fulminant myocarditis, 11 weeks after the first DHS symptoms and the discontinuation of dapsone

Original language	English
Pages (from-to)	89-92
Journal	Netherlands journal of medicine
Volume	74
Issue number	2
Publication status	Published - 2016

Cite this

@article{aee30062efaa4faa9b4031b4aa82a781,

title = "A lethal case of the dapsone hypersensitivity syndrome involving the myocardium",

abstract = "In the Netherlands dapsone is used for the treatment of dermatitis herpetiformis, leprosy and Pneumocystis jiroveci pneumonia and prophylaxis in case of cotrimoxazole allergy. An idiosyncratic drug reaction, known as the dapsone hypersensitivity syndrome (DHS), appears in about 0.5-3.6% of persons treated with dapsone. DHS can be associated with fever, rash and systemic involvement. We present a 35-year-old woman who developed severe DHS seven weeks after starting dapsone. Six weeks after being discharged in a good clinical condition she died from fulminant myocarditis, 11 weeks after the first DHS symptoms and the discontinuation of dapsone",

author = "Hoogeveen, {R. M.} and {van der Bom}, T. and {de Boer}, {H. H.} and Thurlings, {R. M.} and Wind, {B. S.} and {de Vries}, {H. J. C.} and {van Lent}, {A. U.} and U. Beuers and {van der Wal}, {A. C.} and Nellen, {F. J.}",

year = "2016",

language = "English",

volume = "74",

pages = "89--92",

journal = "Netherlands journal of medicine",

issn = "0300-2977",

publisher = "Van Zuiden Communications BV",

number = "2",

}

TY - JOUR

T1 - A lethal case of the dapsone hypersensitivity syndrome involving the myocardium

AU - Hoogeveen, R. M.

AU - van der Bom, T.

AU - de Boer, H. H.

AU - Thurlings, R. M.

AU - Wind, B. S.

AU - de Vries, H. J. C.

AU - van Lent, A. U.

AU - Beuers, U.

AU - van der Wal, A. C.

AU - Nellen, F. J.

PY - 2016

Y1 - 2016

N2 - In the Netherlands dapsone is used for the treatment of dermatitis herpetiformis, leprosy and Pneumocystis jiroveci pneumonia and prophylaxis in case of cotrimoxazole allergy. An idiosyncratic drug reaction, known as the dapsone hypersensitivity syndrome (DHS), appears in about 0.5-3.6% of persons treated with dapsone. DHS can be associated with fever, rash and systemic involvement. We present a 35-year-old woman who developed severe DHS seven weeks after starting dapsone. Six weeks after being discharged in a good clinical condition she died from fulminant myocarditis, 11 weeks after the first DHS symptoms and the discontinuation of dapsone

AB - In the Netherlands dapsone is used for the treatment of dermatitis herpetiformis, leprosy and Pneumocystis jiroveci pneumonia and prophylaxis in case of cotrimoxazole allergy. An idiosyncratic drug reaction, known as the dapsone hypersensitivity syndrome (DHS), appears in about 0.5-3.6% of persons treated with dapsone. DHS can be associated with fever, rash and systemic involvement. We present a 35-year-old woman who developed severe DHS seven weeks after starting dapsone. Six weeks after being discharged in a good clinical condition she died from fulminant myocarditis, 11 weeks after the first DHS symptoms and the discontinuation of dapsone

M3 - Article

C2 - 26951355

SN - 0300-2977

VL - 74

SP - 89

EP - 92

JO - Netherlands journal of medicine

JF - Netherlands journal of medicine

IS - 2

ER -