TY - JOUR
T1 - A lifestyle intervention randomized controlled trial in obese women with infertility improved body composition among those who experienced childhood adversity
AU - van Dammen, Lotte
AU - Bush, Nicole R.
AU - de Rooij, Susanne
AU - Mol, Ben Willem
AU - Mutsaerts, Meike
AU - van Oers, Anne
AU - Groen, Henk
AU - Hoek, Annemieke
AU - Roseboom, Tessa
N1 - Funding Information: We thank all women who participated in the LIFEstyle study and the follow-up visit. We thank all students, PhD students, research nurses and other research personnel involved in the LIFEstyle study and follow-up visit. This research was supported by The Netherlands Organization for Health Research and Development (50-50110-96-518), the Dutch Heart Foundation (grant number: 2013T085) and the European Commission (Horizon2020 project ?DynaHealth?, 633595). The Department of Obstetrics and Gynaecology from the UMCG receives an unrestricted educational grant from Ferring Pharmaceutical BV the Netherlands, unrelated to the present study. Funding Information: We thank all women who participated in the LIFEstyle study and the follow‐up visit. We thank all students, PhD students, research nurses and other research personnel involved in the LIFEstyle study and follow‐up visit. This research was supported by The Netherlands Organization for Health Research and Development (50‐50110‐96‐518), the Dutch Heart Foundation (grant number: 2013T085) and the European Commission (Horizon2020 project ‘DynaHealth’, 633595). The Department of Obstetrics and Gynaecology from the UMCG receives an unrestricted educational grant from Ferring Pharmaceutical BV the Netherlands, unrelated to the present study. Publisher Copyright: © 2020 The Authors. Stress and Health published by John Wiley & Sons Ltd.
PY - 2021/2
Y1 - 2021/2
N2 - Previous research indicates that tailoring lifestyle interventions to participant characteristics optimizes intervention effectiveness. Our objective was to assess whether the effects of a preconception lifestyle intervention in obese infertile women depended on women's exposure to adversity in childhood. A follow-up of a preconception lifestyle intervention randomized controlled trial (the LIFEstyle study) was conducted in the Netherlands among 577 infertile women (age 18–39 years) with a body mass index (BMI) ≥29 kg/m 2 at time of randomization; N = 110 (19%) consented to the follow-up assessment, 6 years later. A 6-month preconception lifestyle intervention aimed weight loss through improving diet and increasing physical activity. The control group received care as usual. Outcome measures included weight, BMI, waist and hip circumference, body fat percentage, blood pressure and metabolic syndrome. The potential moderator, childhood adversity, was assessed with the Life Events Checklist-5 questionnaire. Among the 110 women in our follow-up study, n = 65 (59%) reported no childhood adverse events, n = 28 (25.5%) reported 1 type of childhood adverse events and n = 17 (15.5%) reported ≥2 types of childhood adverse events. Regression models showed significant interactions between childhood adversity and effects of lifestyle intervention at the 6-year follow-up. Among women who experienced childhood adversity, the intervention significantly reduced weight (−10.0 [95% CI −18.5 to −1.5] kg, p = 0.02), BMI (−3.2 [−6.1 to −0.2] kg/m 2, p = 0.04) and body fat percentage (−4.5 [95% CI −7.2 to −1.9] p < 0.01). Among women without childhood adversity, the intervention did not affect these outcomes (2.7 [−3.9 to 9.4] kg, p = 0.42), (0.9 [−1.4 to 3.3] kg/m 2, p = 0.42) and (1.7 [95% CI −0.3 to 3.7] p = 0.10), respectively. Having a history of childhood adversity modified the effect of a preconception lifestyle intervention on women's body composition. If replicated, it may be important to consider childhood adversity as a determinant of lifestyle intervention effectiveness.
AB - Previous research indicates that tailoring lifestyle interventions to participant characteristics optimizes intervention effectiveness. Our objective was to assess whether the effects of a preconception lifestyle intervention in obese infertile women depended on women's exposure to adversity in childhood. A follow-up of a preconception lifestyle intervention randomized controlled trial (the LIFEstyle study) was conducted in the Netherlands among 577 infertile women (age 18–39 years) with a body mass index (BMI) ≥29 kg/m 2 at time of randomization; N = 110 (19%) consented to the follow-up assessment, 6 years later. A 6-month preconception lifestyle intervention aimed weight loss through improving diet and increasing physical activity. The control group received care as usual. Outcome measures included weight, BMI, waist and hip circumference, body fat percentage, blood pressure and metabolic syndrome. The potential moderator, childhood adversity, was assessed with the Life Events Checklist-5 questionnaire. Among the 110 women in our follow-up study, n = 65 (59%) reported no childhood adverse events, n = 28 (25.5%) reported 1 type of childhood adverse events and n = 17 (15.5%) reported ≥2 types of childhood adverse events. Regression models showed significant interactions between childhood adversity and effects of lifestyle intervention at the 6-year follow-up. Among women who experienced childhood adversity, the intervention significantly reduced weight (−10.0 [95% CI −18.5 to −1.5] kg, p = 0.02), BMI (−3.2 [−6.1 to −0.2] kg/m 2, p = 0.04) and body fat percentage (−4.5 [95% CI −7.2 to −1.9] p < 0.01). Among women without childhood adversity, the intervention did not affect these outcomes (2.7 [−3.9 to 9.4] kg, p = 0.42), (0.9 [−1.4 to 3.3] kg/m 2, p = 0.42) and (1.7 [95% CI −0.3 to 3.7] p = 0.10), respectively. Having a history of childhood adversity modified the effect of a preconception lifestyle intervention on women's body composition. If replicated, it may be important to consider childhood adversity as a determinant of lifestyle intervention effectiveness.
KW - childhood adversity
KW - effectiveness
KW - lifestyle intervention
KW - obesity
UR - http://www.scopus.com/inward/record.url?scp=85089528219&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/smi.2976
DO - https://doi.org/10.1002/smi.2976
M3 - Article
C2 - 32761731
SN - 1532-3005
VL - 37
SP - 93
EP - 102
JO - STRESS AND HEALTH
JF - STRESS AND HEALTH
IS - 1
ER -