Abstract
Oxidation-hydrocyanation of γ,δ-unsaturated alcohols using (immobilised) TEMPOXPhI(OAc)2 in combination with HbHNL proceeds smoothly. After (in situ) protection, the resulting cyanohydrin derivatives were obtained in good overall yields and high ee's. A mild TEMPO-catalysed oxidation protocol is described that yields β,γ-unsaturated aldehydes without isomerisation of the double bond and that is compatible with a subsequent HbHNL-catalysed hydrocyanation performed in the same solvent system.
Original language | English |
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Pages (from-to) | 1672-1677 |
Number of pages | 6 |
Journal | European Journal of Organic Chemistry |
Issue number | 7 |
DOIs | |
Publication status | Published - 27 Mar 2006 |
Keywords
- Hydroxynitrile lyase
- Oxidation
- Oxynitrilase
- TEMPO