A multicenter comparison of [18F]flortaucipir, [18F]RO948, and [18F]MK6240 tau PET tracers to detect a common target ROI for differential diagnosis

Antoine Leuzy, Tharick A. Pascoal, Olof Strandberg, Philip Insel, Ruben Smith, Niklas Mattsson-Carlgren, Andréa L. Benedet, Hannah Cho, Chul H. Lyoo, Renaud la Joie, Gil D. Rabinovici, Rik Ossenkoppele, Pedro Rosa-Neto, Oskar Hansson

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Purpose: This study aims to determine whether comparable target regions of interest (ROIs) and cut-offs can be used across [18F]flortaucipir, [18F]RO948, and [18F]MK6240 tau positron emission tomography (PET) tracers for differential diagnosis of Alzheimer’s disease (AD) dementia vs either cognitively unimpaired (CU) individuals or non-AD neurodegenerative diseases. Methods: A total of 1755 participants underwent tau PET using either [18F]flortaucipir (n = 975), [18F]RO948 (n = 493), or [18F]MK6240 (n = 287). SUVR values were calculated across four theory-driven ROIs and several tracer-specific data-driven (hierarchical clustering) regions of interest (ROIs). Diagnostic performance and cut-offs for ROIs were determined using receiver operating characteristic analyses and the Youden index, respectively. Results: Comparable diagnostic performance (area under the receiver operating characteristic curve [AUC]) was observed between theory- and data-driven ROIs. The theory-defined temporal meta-ROI generally performed very well for all three tracers (AUCs: 0.926–0.996). An SUVR value of approximately 1.35 was a common threshold when using this ROI. Conclusion: The temporal meta-ROI can be used for differential diagnosis of dementia patients with [18F]flortaucipir, [18F]RO948, and [18F]MK6240 tau PET with high accuracy, and that using very similar cut-offs of around 1.35 SUVR. This ROI/SUVR cut-off can also be applied across tracers to define tau positivity.
Original languageEnglish
Pages (from-to)2295-2305
Number of pages11
JournalEuropean journal of nuclear medicine and molecular imaging
Issue number7
Early online date2021
Publication statusPublished - Jul 2021


  • PET
  • Tau
  • [ F]Flortaucipir
  • [ F]MK6240
  • [ F]RO948

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