A patient with hyperglycaemia and normal HbA Ic due to impaired glycation

M. J. M. Diekman; H. J. M. Salden; J. H. DeVries

A patient with hyperglycaemia and normal HbA Ic due to impaired glycation

M. J. M. Diekman, H. J. M. Salden, J. H. DeVries

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Scopus)

Abstract

A diabetic Caucasian woman presented with discrepantly low HbA Ic values compared with her glycaemia. High-performance liquid chromatography (HPLC) analysis disclosed 80% HbA and 20% HbI Philadelphia (I6alpha2 lys --> glut). The calculated glycosylation gap from the fructosamine level was 1.2%. The haemoglobin alpha/beta glycation ratios, as measured by electron spray ionisation mass spectroscopy (ESI-MS), for the patient and her three children also carrying the mutation were decreased by values of 0.56 and 0.51, 0.50 and 0.49, respectively (reference value 0.66)

Original language	English
Pages (from-to)	395-397
Journal	Netherlands journal of medicine
Volume	65
Issue number	10
Publication status	Published - 2007

Cite this

@article{6266184904eb4be793b431758d84a477,

title = "A patient with hyperglycaemia and normal HbA Ic due to impaired glycation",

abstract = "A diabetic Caucasian woman presented with discrepantly low HbA Ic values compared with her glycaemia. High-performance liquid chromatography (HPLC) analysis disclosed 80% HbA and 20% HbI Philadelphia (I6alpha2 lys --> glut). The calculated glycosylation gap from the fructosamine level was 1.2%. The haemoglobin alpha/beta glycation ratios, as measured by electron spray ionisation mass spectroscopy (ESI-MS), for the patient and her three children also carrying the mutation were decreased by values of 0.56 and 0.51, 0.50 and 0.49, respectively (reference value 0.66)",

author = "Diekman, {M. J. M.} and Salden, {H. J. M.} and DeVries, {J. H.}",

year = "2007",

language = "English",

volume = "65",

pages = "395--397",

journal = "Netherlands journal of medicine",

issn = "0300-2977",

publisher = "Van Zuiden Communications BV",

number = "10",

}

TY - JOUR

T1 - A patient with hyperglycaemia and normal HbA Ic due to impaired glycation

AU - Diekman, M. J. M.

AU - Salden, H. J. M.

AU - DeVries, J. H.

PY - 2007

Y1 - 2007

N2 - A diabetic Caucasian woman presented with discrepantly low HbA Ic values compared with her glycaemia. High-performance liquid chromatography (HPLC) analysis disclosed 80% HbA and 20% HbI Philadelphia (I6alpha2 lys --> glut). The calculated glycosylation gap from the fructosamine level was 1.2%. The haemoglobin alpha/beta glycation ratios, as measured by electron spray ionisation mass spectroscopy (ESI-MS), for the patient and her three children also carrying the mutation were decreased by values of 0.56 and 0.51, 0.50 and 0.49, respectively (reference value 0.66)

AB - A diabetic Caucasian woman presented with discrepantly low HbA Ic values compared with her glycaemia. High-performance liquid chromatography (HPLC) analysis disclosed 80% HbA and 20% HbI Philadelphia (I6alpha2 lys --> glut). The calculated glycosylation gap from the fructosamine level was 1.2%. The haemoglobin alpha/beta glycation ratios, as measured by electron spray ionisation mass spectroscopy (ESI-MS), for the patient and her three children also carrying the mutation were decreased by values of 0.56 and 0.51, 0.50 and 0.49, respectively (reference value 0.66)

M3 - Article

C2 - 18057463

SN - 0300-2977

VL - 65

SP - 395

EP - 397

JO - Netherlands journal of medicine

JF - Netherlands journal of medicine

IS - 10

ER -