A practical synthesis of capped 4-methylumbelliferyl hyaluronan disaccharides and tetrasaccharides as potential hyaluronidase substrates

Henrik Gold, Stefan Munneke, Jasper Dinkelaar, Herman S. Overkleeft, Johannes M. F. G. Aerts, Jeroen D. C. Codée, Gijs A. van der Marel

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The synthesis of hyaluronan dimers and tetramers equipped with a 4-methylumbelliferyl group at the reducing end to potentially allow monitoring of hyaluronidase activities is described. The 4-OH at the non-reducing glucuronate in the presented series is either removed or methylated to prohibit transglycosylase reactions, leading to a total of four probes
Original languageEnglish
Pages (from-to)1467-1478
JournalCarbohydrate research
Volume346
Issue number12
DOIs
Publication statusPublished - 2011

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