A pregnant patient with ALK-positive non-small cell lung cancer treated with alectinib: A case report and review of the literature

Fabian de Smedt, Frédérique Dessy, Luciano Carestia, Pamela Baldin, Frank Aboubakar Nana, Philippe Clapuyt, V. ronique Boon, Frédéric Amant, Mina Mhallem Gziri

Research output: Contribution to journalReview articleAcademicpeer-review


Oncogenic rearrangements in the anaplastic lymphoma kinase (ALK) gene account for 5% of non-small cell lung cancer (NSCLC) cases. ALK inhibitors have markedly improved the outcome of metastatic ALK-positive NSCLC (ALK+ mNSCLC) by increasing long-term overall survival. Although a diagnosis of NSCLC during pregnancy or the peripartum period is rare, ALK+ NSCLC accounts for 38% of NSCLC cases in women of childbearing age (18-45 years old). The younger age and prolonged survival of patients with ALK+ mNSCLC bring new challenges for lung cancer and obstetrics research, and raises questions related to pregnancy and family planning. The present study described normal fetal development and no obstetric complications in a patient infected with HIV diagnosed with ALK+ mNSCLC, who became pregnant during treatment with alectinib, a third-generation ALK inhibitor.
Original languageEnglish
Article number13640
JournalOncology Letters
Issue number2
Publication statusPublished - 1 Feb 2023


  • alectinib
  • anaplastic lymphoma kinase gene
  • lung cancer
  • pregnancy

Cite this