A prospective longitudinal study on rotation thromboelastometry in women with uncomplicated pregnancies and postpartum

L.E. Flach; S. Zweegman; F. Boersma; J.E. Lenglet; J.W.R. Twisk; A.C. Bolte

doi:https://doi.org/10.1111/ajo.12023

A prospective longitudinal study on rotation thromboelastometry in women with uncomplicated pregnancies and postpartum

L.E. Flach, S. Zweegman, F. Boersma, J.E. Lenglet, J.W.R. Twisk, A.C. Bolte

Research output: Contribution to journal › Article › Academic › peer-review

26 Citations (Scopus)

Abstract

BACKGROUND: Rotation thromboelastometry (ROTEM) is an easy, fast and complete method of measuring coagulation.\n\nAIMS: Our goal was to obtain longitudinal values on ROTEM in uncomplicated pregnancies and in the puerperium.\n\nMATERIALS AND METHODS: Healthy women, who visited our outpatient clinic for antenatal checks and who accomplished an uncomplicated pregnancy were tested three times during pregnancy and one time postpartum. Intrinsic and extrinsic pathway tests were carried out.\n\nRESULTS: In total, 62 women were analysed, and 298 measurements were taken. With increasing gestational age, there are significant changes towards hypercoagulability.\n\nCONCLUSION: This study provides a better knowledge about physiological changes in ROTEM measurements during pregnancy. These normative data may serve as assistance for future studies and interventions.

Original language	English
Pages (from-to)	32-36
Number of pages	5
Journal	ANZJOG
Volume	53
Issue number	1
DOIs	https://doi.org/10.1111/ajo.12023
Publication status	Published - Feb 2013

Keywords

coagulation
maternal haemostatic change
pregnancy
rotation thromboelastometry
thromboelastography

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

https://doi.org/10.1111/ajo.12023

http://www.mendeley.com/research/prospective-longitudinal-study-rotation-thromboelastometry-women-uncomplicated-pregnancies-postpartu

Cite this

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title = "A prospective longitudinal study on rotation thromboelastometry in women with uncomplicated pregnancies and postpartum",

abstract = "BACKGROUND: Rotation thromboelastometry (ROTEM) is an easy, fast and complete method of measuring coagulation.\n\nAIMS: Our goal was to obtain longitudinal values on ROTEM in uncomplicated pregnancies and in the puerperium.\n\nMATERIALS AND METHODS: Healthy women, who visited our outpatient clinic for antenatal checks and who accomplished an uncomplicated pregnancy were tested three times during pregnancy and one time postpartum. Intrinsic and extrinsic pathway tests were carried out.\n\nRESULTS: In total, 62 women were analysed, and 298 measurements were taken. With increasing gestational age, there are significant changes towards hypercoagulability.\n\nCONCLUSION: This study provides a better knowledge about physiological changes in ROTEM measurements during pregnancy. These normative data may serve as assistance for future studies and interventions.",

keywords = "coagulation, maternal haemostatic change, pregnancy, rotation thromboelastometry, thromboelastography",

author = "L.E. Flach and S. Zweegman and F. Boersma and J.E. Lenglet and J.W.R. Twisk and A.C. Bolte",

year = "2013",

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T1 - A prospective longitudinal study on rotation thromboelastometry in women with uncomplicated pregnancies and postpartum

AU - Flach, L.E.

AU - Zweegman, S.

AU - Boersma, F.

AU - Lenglet, J.E.

AU - Twisk, J.W.R.

AU - Bolte, A.C.

PY - 2013/2

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N2 - BACKGROUND: Rotation thromboelastometry (ROTEM) is an easy, fast and complete method of measuring coagulation.\n\nAIMS: Our goal was to obtain longitudinal values on ROTEM in uncomplicated pregnancies and in the puerperium.\n\nMATERIALS AND METHODS: Healthy women, who visited our outpatient clinic for antenatal checks and who accomplished an uncomplicated pregnancy were tested three times during pregnancy and one time postpartum. Intrinsic and extrinsic pathway tests were carried out.\n\nRESULTS: In total, 62 women were analysed, and 298 measurements were taken. With increasing gestational age, there are significant changes towards hypercoagulability.\n\nCONCLUSION: This study provides a better knowledge about physiological changes in ROTEM measurements during pregnancy. These normative data may serve as assistance for future studies and interventions.

AB - BACKGROUND: Rotation thromboelastometry (ROTEM) is an easy, fast and complete method of measuring coagulation.\n\nAIMS: Our goal was to obtain longitudinal values on ROTEM in uncomplicated pregnancies and in the puerperium.\n\nMATERIALS AND METHODS: Healthy women, who visited our outpatient clinic for antenatal checks and who accomplished an uncomplicated pregnancy were tested three times during pregnancy and one time postpartum. Intrinsic and extrinsic pathway tests were carried out.\n\nRESULTS: In total, 62 women were analysed, and 298 measurements were taken. With increasing gestational age, there are significant changes towards hypercoagulability.\n\nCONCLUSION: This study provides a better knowledge about physiological changes in ROTEM measurements during pregnancy. These normative data may serve as assistance for future studies and interventions.

KW - coagulation

KW - maternal haemostatic change

KW - pregnancy

KW - rotation thromboelastometry

KW - thromboelastography

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DO - https://doi.org/10.1111/ajo.12023

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