A review of the clinical experience in pulsed dose rate brachytherapy

Brian V. Balgobind, Kees Koedooder, Diego Ordoñez Zúñiga, Raquel Dávila Fajardo, Coen R. N. Rasch, Bradley R. Pieters

Research output: Contribution to journalReview articleAcademicpeer-review

15 Citations (Scopus)


Pulsed dose rate (PDR) brachytherapy is a treatment modality that combines physical advantages of high dose rate (HDR) brachytherapy with the radiobiological advantages of low dose rate brachytherapy. The aim of this review was to describe the effective clinical use of PDR brachytherapy worldwide in different tumour locations. We found 66 articles reporting on clinical PDR brachytherapy including the treatment procedure and outcome. Moreover, PDR brachytherapy has been applied in almost all tumour sites for which brachytherapy is indicated and with good local control and low toxicity. The main advantage of PDR is, because of the small pulse sizes used, the ability to spare normal tissue. In certain cases, HDR resembles PDR brachytherapy by the use of multifractionated low-fraction dose
Original languageEnglish
Article number20150310
Pages (from-to)20150310
JournalBritish journal of radiology
Issue number1055
Publication statusPublished - 2015

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