A scoring system for predicting malignancy in intraductal papillary mucinous neoplasms of the pancreas: a multicenter EUROPEAN validation

on behalf the Scientific, Research Committee of the European-African Hepato-Pancreato-Biliary Association (E-AHPBA)

doi:https://doi.org/10.1007/s00423-022-02687-2

A scoring system for predicting malignancy in intraductal papillary mucinous neoplasms of the pancreas: a multicenter EUROPEAN validation

on behalf the Scientific, Research Committee of the European-African Hepato-Pancreato-Biliary Association (E-AHPBA)

Research output: Contribution to journal › Article › Academic › peer-review

3 Citations (Scopus)

Abstract

Purpose: A preoperative estimate of the risk of malignancy for intraductal papillary mucinous neoplasms (IPMN) is important. The present study carries out an external validation of the Shin score in a European multicenter cohort. Methods: An observational multicenter European study from 2010 to 2015. All consecutive patients undergoing surgery for IPMN at 35 hospitals with histological-confirmed IPMN were included. Results: A total of 567 patients were included. The score was significantly associated with the presence of malignancy (p < 0.001). In all, 64% of the patients with benign IPMN had a Shin score < 3 and 57% of those with a diagnosis of malignancy had a score ≥ 3. The relative risk (RR) with a Shin score of 3 was 1.37 (95% CI: 1.07–1.77), with a sensitivity of 57.1% and specificity of 64.4%. Conclusion: Patients with a Shin score ≤ 1 should undergo surveillance, while patients with a score ≥ 4 should undergo surgery. Treatment of patients with Shin scores of 2 or 3 should be individualized because these scores cannot accurately predict malignancy of IPMNs. This score should not be the only criterion and should be applied in accordance with agreed clinical guidelines.

Original language	English
Pages (from-to)	3447-3455
Number of pages	9
Journal	Langenbeck's Archives of Surgery
Volume	407
Issue number	8
Early online date	2022
DOIs	https://doi.org/10.1007/s00423-022-02687-2
Publication status	Published - Dec 2022

Keywords

Intraductal papillary mucinous neoplasm
Malignancy
Pancreatic neoplasm
Preoperative diagnosis
Score

Access to Document

https://doi.org/10.1007/s00423-022-02687-2

Cite this

@article{3cfa829fcefc4a378f7abaa0f2170f07,

title = "A scoring system for predicting malignancy in intraductal papillary mucinous neoplasms of the pancreas: a multicenter EUROPEAN validation",

abstract = "Purpose: A preoperative estimate of the risk of malignancy for intraductal papillary mucinous neoplasms (IPMN) is important. The present study carries out an external validation of the Shin score in a European multicenter cohort. Methods: An observational multicenter European study from 2010 to 2015. All consecutive patients undergoing surgery for IPMN at 35 hospitals with histological-confirmed IPMN were included. Results: A total of 567 patients were included. The score was significantly associated with the presence of malignancy (p < 0.001). In all, 64% of the patients with benign IPMN had a Shin score < 3 and 57% of those with a diagnosis of malignancy had a score ≥ 3. The relative risk (RR) with a Shin score of 3 was 1.37 (95% CI: 1.07–1.77), with a sensitivity of 57.1% and specificity of 64.4%. Conclusion: Patients with a Shin score ≤ 1 should undergo surveillance, while patients with a score ≥ 4 should undergo surgery. Treatment of patients with Shin scores of 2 or 3 should be individualized because these scores cannot accurately predict malignancy of IPMNs. This score should not be the only criterion and should be applied in accordance with agreed clinical guidelines.",

keywords = "Intraductal papillary mucinous neoplasm, Malignancy, Pancreatic neoplasm, Preoperative diagnosis, Score",

author = "{on behalf the Scientific, Research Committee of the European-African Hepato-Pancreato-Biliary Association (E-AHPBA)} and Alba Manuel-V{\'a}zquez and Anita Balakrishnan and Paul Agami and Bodil Andersson and Frederik Berrevoet and Besselink, {Marc G.} and Ugo Boggi and Damiano Caputo and Alberto Carabias and Lucia Carrion-Alvarez and Franco, {Carmen Cepeda} and Alessandro Coppola and Dasari, {Bobby V. M.} and Sherley Diaz-Mercedes and Michail Feretis and Constantino Fondevila and Fusai, {Giuseppe Kito} and Giuseppe Garcea and Victor Gonzabay and Bravo, {Miguel {\'A}ngel G. mez} and Myrte Gorris and Bart Hendrikx and Camila Hidalgo-Salinas and Prashant Kadam and Dimitrios Karavias and Emanuele Kauffmann and Amar Kourdouli and {la Vaccara}, Vincenzo and {van Laarhoven}, Stijn and James Leighton and Liem, {Mike S. L.} and Nikolaos Machairas and Dimitris Magouliotis and Adel Mahmoud and Marino, {Marco V.} and Marco Massani and Requena, {Paola Melgar} and Keno Mentor and Niccol{\`o} Napoli and Nijhuis, {Jorieke H. T.} and Andrej Nikov and Cristina Nistri and Victor Nunes and Ruiz, {Eduardo Ortiz} and Sanjay Pandanaboyana and Saborido, {Baltasar P. rez} and Radek Pohn{\'a}n and Mariuca Popa and P{\'e}rez, {Belinda S. nchez} and Bueno, {Francisco S. nchez}",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.",

year = "2022",

month = dec,

doi = "https://doi.org/10.1007/s00423-022-02687-2",

language = "English",

volume = "407",

pages = "3447--3455",

journal = "Langenbeck's Archives of Surgery",

issn = "1435-2443",

publisher = "Springer Verlag",

number = "8",

}

on behalf the Scientific, Research Committee of the European-African Hepato-Pancreato-Biliary Association (E-AHPBA) 2022, 'A scoring system for predicting malignancy in intraductal papillary mucinous neoplasms of the pancreas: a multicenter EUROPEAN validation', Langenbeck's Archives of Surgery, vol. 407, no. 8, pp. 3447-3455. https://doi.org/10.1007/s00423-022-02687-2

A scoring system for predicting malignancy in intraductal papillary mucinous neoplasms of the pancreas: a multicenter EUROPEAN validation. / on behalf the Scientific, Research Committee of the European-African Hepato-Pancreato-Biliary Association (E-AHPBA).
In: Langenbeck's Archives of Surgery, Vol. 407, No. 8, 12.2022, p. 3447-3455.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - A scoring system for predicting malignancy in intraductal papillary mucinous neoplasms of the pancreas

T2 - a multicenter EUROPEAN validation

AU - on behalf the Scientific, Research Committee of the European-African Hepato-Pancreato-Biliary Association (E-AHPBA)

AU - Manuel-Vázquez, Alba

AU - Balakrishnan, Anita

AU - Agami, Paul

AU - Andersson, Bodil

AU - Berrevoet, Frederik

AU - Besselink, Marc G.

AU - Boggi, Ugo

AU - Caputo, Damiano

AU - Carabias, Alberto

AU - Carrion-Alvarez, Lucia

AU - Franco, Carmen Cepeda

AU - Coppola, Alessandro

AU - Dasari, Bobby V. M.

AU - Diaz-Mercedes, Sherley

AU - Feretis, Michail

AU - Fondevila, Constantino

AU - Fusai, Giuseppe Kito

AU - Garcea, Giuseppe

AU - Gonzabay, Victor

AU - Bravo, Miguel Ángel G. mez

AU - Gorris, Myrte

AU - Hendrikx, Bart

AU - Hidalgo-Salinas, Camila

AU - Kadam, Prashant

AU - Karavias, Dimitrios

AU - Kauffmann, Emanuele

AU - Kourdouli, Amar

AU - la Vaccara, Vincenzo

AU - van Laarhoven, Stijn

AU - Leighton, James

AU - Liem, Mike S. L.

AU - Machairas, Nikolaos

AU - Magouliotis, Dimitris

AU - Mahmoud, Adel

AU - Marino, Marco V.

AU - Massani, Marco

AU - Requena, Paola Melgar

AU - Mentor, Keno

AU - Napoli, Niccolò

AU - Nijhuis, Jorieke H. T.

AU - Nikov, Andrej

AU - Nistri, Cristina

AU - Nunes, Victor

AU - Ruiz, Eduardo Ortiz

AU - Pandanaboyana, Sanjay

AU - Saborido, Baltasar P. rez

AU - Pohnán, Radek

AU - Popa, Mariuca

AU - Pérez, Belinda S. nchez

AU - Bueno, Francisco S. nchez

PY - 2022/12

Y1 - 2022/12

N2 - Purpose: A preoperative estimate of the risk of malignancy for intraductal papillary mucinous neoplasms (IPMN) is important. The present study carries out an external validation of the Shin score in a European multicenter cohort. Methods: An observational multicenter European study from 2010 to 2015. All consecutive patients undergoing surgery for IPMN at 35 hospitals with histological-confirmed IPMN were included. Results: A total of 567 patients were included. The score was significantly associated with the presence of malignancy (p < 0.001). In all, 64% of the patients with benign IPMN had a Shin score < 3 and 57% of those with a diagnosis of malignancy had a score ≥ 3. The relative risk (RR) with a Shin score of 3 was 1.37 (95% CI: 1.07–1.77), with a sensitivity of 57.1% and specificity of 64.4%. Conclusion: Patients with a Shin score ≤ 1 should undergo surveillance, while patients with a score ≥ 4 should undergo surgery. Treatment of patients with Shin scores of 2 or 3 should be individualized because these scores cannot accurately predict malignancy of IPMNs. This score should not be the only criterion and should be applied in accordance with agreed clinical guidelines.

AB - Purpose: A preoperative estimate of the risk of malignancy for intraductal papillary mucinous neoplasms (IPMN) is important. The present study carries out an external validation of the Shin score in a European multicenter cohort. Methods: An observational multicenter European study from 2010 to 2015. All consecutive patients undergoing surgery for IPMN at 35 hospitals with histological-confirmed IPMN were included. Results: A total of 567 patients were included. The score was significantly associated with the presence of malignancy (p < 0.001). In all, 64% of the patients with benign IPMN had a Shin score < 3 and 57% of those with a diagnosis of malignancy had a score ≥ 3. The relative risk (RR) with a Shin score of 3 was 1.37 (95% CI: 1.07–1.77), with a sensitivity of 57.1% and specificity of 64.4%. Conclusion: Patients with a Shin score ≤ 1 should undergo surveillance, while patients with a score ≥ 4 should undergo surgery. Treatment of patients with Shin scores of 2 or 3 should be individualized because these scores cannot accurately predict malignancy of IPMNs. This score should not be the only criterion and should be applied in accordance with agreed clinical guidelines.

KW - Intraductal papillary mucinous neoplasm

KW - Malignancy

KW - Pancreatic neoplasm

KW - Preoperative diagnosis

KW - Score

UR - http://www.scopus.com/inward/record.url?scp=85139612845&partnerID=8YFLogxK

U2 - https://doi.org/10.1007/s00423-022-02687-2

DO - https://doi.org/10.1007/s00423-022-02687-2

M3 - Article

C2 - 36198881

SN - 1435-2443

VL - 407

SP - 3447

EP - 3455

JO - Langenbeck's Archives of Surgery

JF - Langenbeck's Archives of Surgery

IS - 8

ER -

on behalf the Scientific, Research Committee of the European-African Hepato-Pancreato-Biliary Association (E-AHPBA). A scoring system for predicting malignancy in intraductal papillary mucinous neoplasms of the pancreas: a multicenter EUROPEAN validation. Langenbeck's Archives of Surgery. 2022 Dec;407(8):3447-3455. Epub 2022. doi: https://doi.org/10.1007/s00423-022-02687-2

A scoring system for predicting malignancy in intraductal papillary mucinous neoplasms of the pancreas: a multicenter EUROPEAN validation

Abstract

Keywords

Access to Document

Other files and links

Cite this