TY - JOUR
T1 - A study in three European IBD cohorts confirms that the ATG16L1 c.898A > G (p.Thr300Ala) variant is a susceptibility factor for Crohn's disease
AU - Büning, Carsten
AU - Durmus, Tahir
AU - Molnar, Tamas
AU - de Jong, Dirk J.
AU - Drenth, Joost P. H.
AU - Fiedler, Thomas
AU - Gentz, Enno
AU - Todorov, Theodor
AU - Haas, Verena
AU - Buhner, Sabine
AU - Sturm, Andreas
AU - Baumgart, Daniel C.
AU - Nagy, Ferenc
AU - Lonovics, Janos
AU - Landt, Olfert
AU - Kage, Andreas
AU - Büning, Herbert
AU - Nickel, Renate
AU - Büttner, Janine
AU - Lochs, Herbert
AU - Schmidt, Hartmut H. -J.
AU - Witt, Heiko
PY - 2007/12
Y1 - 2007/12
N2 - Background and aims: A recent study reported that a nonsynonymous SNP rs2241880 (c.898A > G, p.Thr300Ala) within ATG16L1 confers susceptibility to Crohn's disease (CD). We analyzed ATG16L1 c.898A > G in three independent European inflammatory bowel disease (IBD) cohorts from Germany, Hungary and the Netherlands. Methods: In total, we included 910 European IBD patients and compared the ATG16L1 c.898A > G genotype frequency with 707 ethnically matched healthy controls. We included patients from 3 populations originating from Germany (CD n = 310; ulcerative colitis [UC] n = 179), Hungary (CD n = 147; UC n = 117), and the Netherlands (CD n = 157). Subtyping analysis was performed in respect to CARD15 alterations and clinical characteristics. Results: We found a highly significant association of c.898A > G to CD. The association was significant (p = 0.0005) for the total CD cohort but also for the individual populations from Germany (p = 0.02) and Netherlands (p = 0.02) whereas in the Hungarian CD patients a clear trend was observed (p = 0.19; OR 1.227, 95% CI 0.910; 1.654). No association was found between c.898A > G and UC. No statistical interactions were observed between ATG16L1 c.898A > G and CARD15 variants. Furthermore no association to a CD subphenotype was detected. Conclusions: We confirm that ATG16L1 variant c898A > G confers a risk variant for CD but is not associated with a distinct CD phenotype. © 2007 European Crohn's and Colitis Organization.
AB - Background and aims: A recent study reported that a nonsynonymous SNP rs2241880 (c.898A > G, p.Thr300Ala) within ATG16L1 confers susceptibility to Crohn's disease (CD). We analyzed ATG16L1 c.898A > G in three independent European inflammatory bowel disease (IBD) cohorts from Germany, Hungary and the Netherlands. Methods: In total, we included 910 European IBD patients and compared the ATG16L1 c.898A > G genotype frequency with 707 ethnically matched healthy controls. We included patients from 3 populations originating from Germany (CD n = 310; ulcerative colitis [UC] n = 179), Hungary (CD n = 147; UC n = 117), and the Netherlands (CD n = 157). Subtyping analysis was performed in respect to CARD15 alterations and clinical characteristics. Results: We found a highly significant association of c.898A > G to CD. The association was significant (p = 0.0005) for the total CD cohort but also for the individual populations from Germany (p = 0.02) and Netherlands (p = 0.02) whereas in the Hungarian CD patients a clear trend was observed (p = 0.19; OR 1.227, 95% CI 0.910; 1.654). No association was found between c.898A > G and UC. No statistical interactions were observed between ATG16L1 c.898A > G and CARD15 variants. Furthermore no association to a CD subphenotype was detected. Conclusions: We confirm that ATG16L1 variant c898A > G confers a risk variant for CD but is not associated with a distinct CD phenotype. © 2007 European Crohn's and Colitis Organization.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=37249054533&origin=inward
U2 - https://doi.org/10.1016/j.crohns.2007.08.001
DO - https://doi.org/10.1016/j.crohns.2007.08.001
M3 - Article
SN - 1873-9946
VL - 1
SP - 70
EP - 76
JO - Journal of Crohn's and Colitis
JF - Journal of Crohn's and Colitis
IS - 2
ER -