TY - JOUR
T1 - A unidirectional but not uniform striatal landscape of dopamine signaling for motivational stimuli
AU - van Elzelingen, Wouter
AU - Goedhoop, Jessica
AU - Warnaar, Pascal
AU - Denys, Damiaan
AU - Arbab, Tara
AU - Willuhn, Ingo
N1 - Funding Information: 638013 to I.W.) and the Netherlands Organization for Scientific Research (Grants 864.14.010, 2015/06367/ALW and BRAINSCAPES 024.004.012 to I.W.). Funding Information: ACKNOWLEDGMENTS. We thank Ralph Hamelink and Nicole Yee for their technical support, and Matthijs Feenstra for his input on the manuscript. This research was funded by the European Research Council (Grant ERC-2014-STG Publisher Copyright: Copyright © 2022 the Author(s).
PY - 2022/5/24
Y1 - 2022/5/24
N2 - Dopamine signals in the striatum are critical for motivated behavior. However, their regional specificity and precise information content are actively debated. Dopaminergic projections to the striatum are topographically organized. Thus, we quantified dopamine release in response to motivational stimuli and associated predictive cues in six principal striatal regions of unrestrained, behaving rats. Absolute signal size and its modulation by stimulus value and by subjective state of the animal were interregionally heterogeneous on a medial to lateral gradient. In contrast, dopamine-concentration direction of change was homogeneous across all regions: appetitive stimuli increased and aversive stimuli decreased dopamine concentration. Although cues predictive of such motivational stimuli acquired the same influence over dopamine homogeneously across all regions, dopamine-mediated prediction-error signals were restricted to the ventromedial, limbic striatum. Together, our findings demonstrate a nuanced striatal landscape of unidirectional but not uniform dopamine signals, topographically encoding distinct aspects of motivational stimuli and their prediction.
AB - Dopamine signals in the striatum are critical for motivated behavior. However, their regional specificity and precise information content are actively debated. Dopaminergic projections to the striatum are topographically organized. Thus, we quantified dopamine release in response to motivational stimuli and associated predictive cues in six principal striatal regions of unrestrained, behaving rats. Absolute signal size and its modulation by stimulus value and by subjective state of the animal were interregionally heterogeneous on a medial to lateral gradient. In contrast, dopamine-concentration direction of change was homogeneous across all regions: appetitive stimuli increased and aversive stimuli decreased dopamine concentration. Although cues predictive of such motivational stimuli acquired the same influence over dopamine homogeneously across all regions, dopamine-mediated prediction-error signals were restricted to the ventromedial, limbic striatum. Together, our findings demonstrate a nuanced striatal landscape of unidirectional but not uniform dopamine signals, topographically encoding distinct aspects of motivational stimuli and their prediction.
KW - Pavlovian conditioning
KW - behavior
KW - dopamine
KW - motivation
KW - striatum
UR - http://www.scopus.com/inward/record.url?scp=85130862364&partnerID=8YFLogxK
U2 - https://doi.org/10.1073/pnas.2117270119
DO - https://doi.org/10.1073/pnas.2117270119
M3 - Article
C2 - 35594399
SN - 0027-8424
VL - 119
JO - PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
JF - PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IS - 21
M1 - e2117270119
ER -