COMT Val158Met genotype and cannabis use in people with an At Risk Mental State for psychosis: Exploring Gene x Environment interactions

D.H. Nieman; S. Dragt; E.D.A. van Duin; N. Denneman; J.M. Overbeek; L. de Haan; J. Rietdijk; H Ising; R.M.C. Klaassen; T. van Amelsvoort; L. Wunderink; M. van der Gaag; D.H. Linszen

doi:https://doi.org/10.1016/j.schres.2016.03.015

COMT Val158Met genotype and cannabis use in people with an At Risk Mental State for psychosis: Exploring Gene x Environment interactions

D.H. Nieman, S. Dragt, E.D.A. van Duin, N. Denneman, J.M. Overbeek, L. de Haan, J. Rietdijk, H Ising, R.M.C. Klaassen, T. van Amelsvoort, L. Wunderink, M. van der Gaag, D.H. Linszen

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Abstract

Epidemiological and retrospective studies suggest a cannabis x catechol-O-methyltransferase (COMT) Val(158)Met interaction effect on development of psychosis. The aim of this study was to examine this interaction and its association with severity of subclinical symptoms in people with an At Risk Mental State (ARMS) for psychosis. Severity of symptoms, cannabis use and genotype were assessed at baseline in 147 help-seeking young adults who met the ARMS criteria and agreed to participate in the Dutch Early Detection and Intervention (EDIE-NL) trial. Cannabis use and COMT Val-allele showed an interaction effect in ARMS subjects. Subjects who were weekly cannabis users at some point prior to entering the study showed more severe positive symptoms. This effect increased if they were carriers of the COMT Val-allele and even more so if they were homozygous for the Val-allele. Our results suggest that the COMT Val(158)Met polymorphism moderates the effect of regular cannabis use on severity of subclinical psychotic symptoms

Original language	English
Pages (from-to)	24-28
Number of pages	4
Journal	Schizophrenia Research
Volume	2016
Issue number	174
DOIs	https://doi.org/10.1016/j.schres.2016.03.015
Publication status	Published - 2016

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Nieman, D. H., Dragt, S., van Duin, E. D. A., Denneman, N., Overbeek, J. M., de Haan, L., Rietdijk, J., Ising, H., Klaassen, R. M. C., van Amelsvoort, T., Wunderink, L., van der Gaag, M., & Linszen, D. H. (2016). COMT Val158Met genotype and cannabis use in people with an At Risk Mental State for psychosis: Exploring Gene x Environment interactions. Schizophrenia Research, 2016(174), 24-28. https://doi.org/10.1016/j.schres.2016.03.015

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title = "COMT Val158Met genotype and cannabis use in people with an At Risk Mental State for psychosis: Exploring Gene x Environment interactions",

abstract = "Epidemiological and retrospective studies suggest a cannabis x catechol-O-methyltransferase (COMT) Val(158)Met interaction effect on development of psychosis. The aim of this study was to examine this interaction and its association with severity of subclinical symptoms in people with an At Risk Mental State (ARMS) for psychosis. Severity of symptoms, cannabis use and genotype were assessed at baseline in 147 help-seeking young adults who met the ARMS criteria and agreed to participate in the Dutch Early Detection and Intervention (EDIE-NL) trial. Cannabis use and COMT Val-allele showed an interaction effect in ARMS subjects. Subjects who were weekly cannabis users at some point prior to entering the study showed more severe positive symptoms. This effect increased if they were carriers of the COMT Val-allele and even more so if they were homozygous for the Val-allele. Our results suggest that the COMT Val(158)Met polymorphism moderates the effect of regular cannabis use on severity of subclinical psychotic symptoms",

author = "D.H. Nieman and S. Dragt and {van Duin}, E.D.A. and N. Denneman and J.M. Overbeek and {de Haan}, L. and J. Rietdijk and H Ising and R.M.C. Klaassen and {van Amelsvoort}, T. and L. Wunderink and {van der Gaag}, M. and D.H. Linszen",

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Nieman, DH, Dragt, S, van Duin, EDA, Denneman, N, Overbeek, JM, de Haan, L, Rietdijk, J, Ising, H, Klaassen, RMC, van Amelsvoort, T, Wunderink, L, van der Gaag, M & Linszen, DH 2016, 'COMT Val158Met genotype and cannabis use in people with an At Risk Mental State for psychosis: Exploring Gene x Environment interactions', Schizophrenia Research, vol. 2016, no. 174, pp. 24-28. https://doi.org/10.1016/j.schres.2016.03.015

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T1 - COMT Val158Met genotype and cannabis use in people with an At Risk Mental State for psychosis: Exploring Gene x Environment interactions

AU - Nieman, D.H.

AU - Dragt, S.

AU - van Duin, E.D.A.

AU - Denneman, N.

AU - Overbeek, J.M.

AU - de Haan, L.

AU - Rietdijk, J.

AU - Ising, H

AU - Klaassen, R.M.C.

AU - van Amelsvoort, T.

AU - Wunderink, L.

AU - van der Gaag, M.

AU - Linszen, D.H.

PY - 2016

Y1 - 2016

N2 - Epidemiological and retrospective studies suggest a cannabis x catechol-O-methyltransferase (COMT) Val(158)Met interaction effect on development of psychosis. The aim of this study was to examine this interaction and its association with severity of subclinical symptoms in people with an At Risk Mental State (ARMS) for psychosis. Severity of symptoms, cannabis use and genotype were assessed at baseline in 147 help-seeking young adults who met the ARMS criteria and agreed to participate in the Dutch Early Detection and Intervention (EDIE-NL) trial. Cannabis use and COMT Val-allele showed an interaction effect in ARMS subjects. Subjects who were weekly cannabis users at some point prior to entering the study showed more severe positive symptoms. This effect increased if they were carriers of the COMT Val-allele and even more so if they were homozygous for the Val-allele. Our results suggest that the COMT Val(158)Met polymorphism moderates the effect of regular cannabis use on severity of subclinical psychotic symptoms

AB - Epidemiological and retrospective studies suggest a cannabis x catechol-O-methyltransferase (COMT) Val(158)Met interaction effect on development of psychosis. The aim of this study was to examine this interaction and its association with severity of subclinical symptoms in people with an At Risk Mental State (ARMS) for psychosis. Severity of symptoms, cannabis use and genotype were assessed at baseline in 147 help-seeking young adults who met the ARMS criteria and agreed to participate in the Dutch Early Detection and Intervention (EDIE-NL) trial. Cannabis use and COMT Val-allele showed an interaction effect in ARMS subjects. Subjects who were weekly cannabis users at some point prior to entering the study showed more severe positive symptoms. This effect increased if they were carriers of the COMT Val-allele and even more so if they were homozygous for the Val-allele. Our results suggest that the COMT Val(158)Met polymorphism moderates the effect of regular cannabis use on severity of subclinical psychotic symptoms

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DO - https://doi.org/10.1016/j.schres.2016.03.015

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