TY - JOUR
T1 - Anaemia, iron deficiency and susceptibility to infections
AU - Jonker, Femke A. M.
AU - Boele van Hensbroek, Michaël
PY - 2014
Y1 - 2014
N2 - Anaemia, iron deficiency and infections are three major causes of childhood morbidity and mortality throughout the world, although they predominantly occur in resource limited settings. As the three conditions may have the same underlying aetiologies, they often occur simultaneously and may interact. Being an essential component in erythropoiesis, iron is also essential for proper functioning of the host immune system as well as an essential nutrient for growth of various pathogens, including non-typhoid salmonella. This has resulted in a treatment dilemma in which iron is needed to treat the iron deficient anaemia and improve the immune system of the host (child), but the same treatment may also put the child at an increased, potentially fatal, infection risk
AB - Anaemia, iron deficiency and infections are three major causes of childhood morbidity and mortality throughout the world, although they predominantly occur in resource limited settings. As the three conditions may have the same underlying aetiologies, they often occur simultaneously and may interact. Being an essential component in erythropoiesis, iron is also essential for proper functioning of the host immune system as well as an essential nutrient for growth of various pathogens, including non-typhoid salmonella. This has resulted in a treatment dilemma in which iron is needed to treat the iron deficient anaemia and improve the immune system of the host (child), but the same treatment may also put the child at an increased, potentially fatal, infection risk
U2 - https://doi.org/10.1016/j.jinf.2014.08.007
DO - https://doi.org/10.1016/j.jinf.2014.08.007
M3 - Article
C2 - 25264159
SN - 0163-4453
VL - 69
SP - S23-S27
JO - Journal of Infection
JF - Journal of Infection
IS - Suppl. 1
ER -