Abdominal computed tomography in refractory coeliac disease and enteropathy associated T-cell lymphoma

Maarten Mallant, Muhammed Hadithi, Abdul-Baqi Al-Toma, Matthijs Kater, Maarten Jacobs, Radu Manoliu, Chris Mulder, Jan-Hein van Waesberghe

Research output: Contribution to journalArticleAcademicpeer-review


AIM: To evaluate computed tomography (CT) findings, useful to suggest the presence of refractory celiac disease (RCD) and enteropathy associated T cell lymphoma (EATL).

METHODS: Coeliac disease (CD) patients were divided into two groups. Group I: uncomplicated CD (n = 14) and RCD type I (n = 10). Group II: RCD type II (n = 15) and EATL (n = 7).

RESULTS: Both groups showed classic signs of CD on CT. Intussusception was seen in 1 patient in group I vs 5 in group II (P = 0.06). Lymphadenopathy was seen in 5 patients in group II vs no patients in group I (P = 0.01). Increased number of small mesenteric vessels was noted in 20 patients in group I vs 11 in group II (P = 0.02). Eleven patients (50%) in group II had a splenic volume < 122 cm3 vs 4 in group I (14%), 10 patients in group I had a splenic volume > 196 cm3 (66.7%) vs 5 in group II (33.3%) P = 0.028.

CONCLUSION: CT scan is a useful tool in discriminating between CD and (Pre) EATL. RCD II and EATL showed more bowel wall thickening, lymphadenopathy and intussusception, less increase in number of small mesenteric vessels and a smaller splenic volume compared with CD and RCD I.

Original languageEnglish
Pages (from-to)1696-700
Number of pages5
JournalWorld journal of gastroenterology
Issue number11
Publication statusPublished - 21 Mar 2007


  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Celiac Disease/complications
  • Diagnosis, Differential
  • Female
  • Humans
  • Intestines/diagnostic imaging
  • Lymphoma, T-Cell/complications
  • Male
  • Mesentery/blood supply
  • Middle Aged
  • Organ Size
  • Radiography, Abdominal/methods
  • Spleen/pathology
  • Tomography, X-Ray Computed/methods

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