A series of case studies illustrating the role of flow cytometry in the diagnostic work-up of myelodysplastic syndromes

Theresia M. Westers, Leonie Saft, Vincent H. J. van der Velden, Jeroen G. te Marvelde, Alan Dunlop, Robin Ireland, Peter Valent, Anna Porwit, Marie C. Béné, Arjan A. van de Loosdrecht

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Current guidelines recommend flow cytometric analysis as part of the diagnostic assessment of patients with cytopenia suspected for myelodysplastic syndrome. Herein we describe the complete work-up of six cases using multimodal integrated diagnostics. Flow cytometry assessments are illustrated by plots from conventional and more recent analysis tools. The cases demonstrate the added value of flow cytometry in case of hypocellular, poor quality, or ambiguous bone marrow cytomorphology. Moreover, they demonstrate how immunophenotyping results support clinical decision-making in inconclusive and clinically ‘difficult’ cases.
Original languageEnglish
Pages (from-to)87-97
Number of pages11
JournalCytometry. Part B, Clinical cytometry
Volume104
Issue number1
Early online date2022
DOIs
Publication statusPublished - 15 Jan 2023

Keywords

  • MDS
  • cytopenia
  • dysplasia
  • flow cytometry
  • integrated diagnostics

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