TY - JOUR
T1 - A series of case studies illustrating the role of flow cytometry in the diagnostic work-up of myelodysplastic syndromes
AU - Westers, Theresia M.
AU - Saft, Leonie
AU - van der Velden, Vincent H. J.
AU - te Marvelde, Jeroen G.
AU - Dunlop, Alan
AU - Ireland, Robin
AU - Valent, Peter
AU - Porwit, Anna
AU - Béné, Marie C.
AU - van de Loosdrecht, Arjan A.
N1 - Publisher Copyright: © 2022 The Authors. Cytometry Part B: Clinical Cytometry published by Wiley Periodicals LLC on behalf of International Clinical Cytometry Society.
PY - 2023/1/15
Y1 - 2023/1/15
N2 - Current guidelines recommend flow cytometric analysis as part of the diagnostic assessment of patients with cytopenia suspected for myelodysplastic syndrome. Herein we describe the complete work-up of six cases using multimodal integrated diagnostics. Flow cytometry assessments are illustrated by plots from conventional and more recent analysis tools. The cases demonstrate the added value of flow cytometry in case of hypocellular, poor quality, or ambiguous bone marrow cytomorphology. Moreover, they demonstrate how immunophenotyping results support clinical decision-making in inconclusive and clinically ‘difficult’ cases.
AB - Current guidelines recommend flow cytometric analysis as part of the diagnostic assessment of patients with cytopenia suspected for myelodysplastic syndrome. Herein we describe the complete work-up of six cases using multimodal integrated diagnostics. Flow cytometry assessments are illustrated by plots from conventional and more recent analysis tools. The cases demonstrate the added value of flow cytometry in case of hypocellular, poor quality, or ambiguous bone marrow cytomorphology. Moreover, they demonstrate how immunophenotyping results support clinical decision-making in inconclusive and clinically ‘difficult’ cases.
KW - MDS
KW - cytopenia
KW - dysplasia
KW - flow cytometry
KW - integrated diagnostics
UR - http://www.scopus.com/inward/record.url?scp=85124725693&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/cyto.b.22061
DO - https://doi.org/10.1002/cyto.b.22061
M3 - Article
C2 - 35179296
SN - 1552-4949
VL - 104
SP - 87
EP - 97
JO - Cytometry. Part B, Clinical cytometry
JF - Cytometry. Part B, Clinical cytometry
IS - 1
ER -