TY - JOUR
T1 - Actions of metformin and statins on lipid and glucose metabolism and possible benefit of combination therapy
AU - van Stee, Mariël F.
AU - de Graaf, Albert A.
AU - Groen, Albert K.
PY - 2018
Y1 - 2018
N2 - Patients with diabetes type 2 have an increased risk for cardiovascular disease and commonly use combination therapy consisting of the anti-diabetic drug metformin and a cholesterol-lowering statin. However, both drugs act on glucose and lipid metabolism which could lead to adverse effects when used in combination as compared to monotherapy. In this review, the proposed molecular mechanisms of action of statin and metformin therapy in patients with diabetes and dyslipidemia are critically assessed, and a hypothesis for mechanisms underlying interactions between these drugs in combination therapy is developed.
AB - Patients with diabetes type 2 have an increased risk for cardiovascular disease and commonly use combination therapy consisting of the anti-diabetic drug metformin and a cholesterol-lowering statin. However, both drugs act on glucose and lipid metabolism which could lead to adverse effects when used in combination as compared to monotherapy. In this review, the proposed molecular mechanisms of action of statin and metformin therapy in patients with diabetes and dyslipidemia are critically assessed, and a hypothesis for mechanisms underlying interactions between these drugs in combination therapy is developed.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85049243274&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29960584
U2 - https://doi.org/10.1186/s12933-018-0738-4
DO - https://doi.org/10.1186/s12933-018-0738-4
M3 - Review article
C2 - 29960584
SN - 1475-2840
VL - 17
JO - Cardiovascular diabetology
JF - Cardiovascular diabetology
IS - 1
M1 - 94
ER -