TY - JOUR
T1 - Acute basilar artery occlusion in the Basilar Artery International Cooperation Study: does gender matter?
AU - Arnold, Marcel
AU - Fischer, Urs
AU - Compter, Annette
AU - Gralla, Jan
AU - Findling, Oliver
AU - Mattle, Heinrich P.
AU - Kappelle, L. Jaap
AU - Tanne, David
AU - Algra, Ale
AU - Schonewille, Wouter J.
AU - AUTHOR GROUP
AU - Weber, A. M.
AU - Donnan, G. A.
AU - Thijs, V.
AU - Peeters, A.
AU - de Freitas, G.
AU - Conforto, A. B.
AU - Miranda-Alves, A.
AU - Massaro, A.
AU - Ijäs, P.
AU - Bogoslovsky, T.
AU - Lindsberg, P. J.
AU - Weimar, C.
AU - Benemann, J.
AU - Kraywinkel, K.
AU - Haverkamp, C.
AU - Michalski, D.
AU - Weissenborn, K.
AU - Goertler, M.
AU - Kloth, A.
AU - Bitsch, A.
AU - Mieck, T.
AU - Machetanz, J.
AU - Möller, P.
AU - Huber, R.
AU - Kaendler, S.
AU - Rueckert, C.
AU - Audebert, H.
AU - Müller, R.
AU - Vatankhah, B.
AU - Pfefferkorn, T.
AU - Mayer, T. E.
AU - Szabo, K.
AU - Disque, C.
AU - Busse, O.
AU - Berger, C.
AU - Hacke, W.
AU - Schwammenthal, Y.
AU - Vergouwen, M. D.
AU - Roos, Y.
AU - Stam, J.
PY - 2010
Y1 - 2010
N2 - Randomized trials suggested a different benefit of intravenous thrombolysis (IVT) and intra-arterial thrombolysis (IAT) between men and women with anterior circulation stroke because of a worse outcome of women in the control group. We compared outcome and recanalization in men and women with basilar artery occlusion treated with antithrombotic treatment alone, IVT or combined IVT-IAT, or IAT in the Basilar Artery International Cooperation Study. Overall, 389 male and 226 female patients were analyzed. In the antithrombotic treatment group, 68 of 111 (61%) men and 47 of 70 (67%) women had a poor outcome defined as a modified Rankin Scale score of 4 to 6 (adjusted risk ratio [aRR], 0.96; 95% CI, 0.75 to 1.24), in the IVT/combined IVT-IAT group, 47 of 77 (61%) men and 24 of 43 (56%) women (aRR, 1.19; 95% CI, 0.89 to 1.60), and in the IAT group, 142 of 185 (77%) men and 71 of 102 (70%) women (aRR, 1.01; 95% CI, 0.88 to 1.17). Mortality was not different between men and women in the antithrombotic treatment group (aRR, 0.80; 95% CI, 0.55 to 1.16), the IVT/combined IVT-IAT group (aRR, 1.11; 95% CI, 0.72 to 1.73), or in the IAT group (aRR, 1.01; 95% CI, 0.75 to 1.36). Insufficient recanalization after combined IVT-IAT or IAT was similar in men and women (23% versus 22%; aRR, 0.92; 95% CI, 0.58 to 1.46). In patients with acute basilar artery occlusion, no significant gender differences for outcome and recanalization were observed, regardless of treatment modality
AB - Randomized trials suggested a different benefit of intravenous thrombolysis (IVT) and intra-arterial thrombolysis (IAT) between men and women with anterior circulation stroke because of a worse outcome of women in the control group. We compared outcome and recanalization in men and women with basilar artery occlusion treated with antithrombotic treatment alone, IVT or combined IVT-IAT, or IAT in the Basilar Artery International Cooperation Study. Overall, 389 male and 226 female patients were analyzed. In the antithrombotic treatment group, 68 of 111 (61%) men and 47 of 70 (67%) women had a poor outcome defined as a modified Rankin Scale score of 4 to 6 (adjusted risk ratio [aRR], 0.96; 95% CI, 0.75 to 1.24), in the IVT/combined IVT-IAT group, 47 of 77 (61%) men and 24 of 43 (56%) women (aRR, 1.19; 95% CI, 0.89 to 1.60), and in the IAT group, 142 of 185 (77%) men and 71 of 102 (70%) women (aRR, 1.01; 95% CI, 0.88 to 1.17). Mortality was not different between men and women in the antithrombotic treatment group (aRR, 0.80; 95% CI, 0.55 to 1.16), the IVT/combined IVT-IAT group (aRR, 1.11; 95% CI, 0.72 to 1.73), or in the IAT group (aRR, 1.01; 95% CI, 0.75 to 1.36). Insufficient recanalization after combined IVT-IAT or IAT was similar in men and women (23% versus 22%; aRR, 0.92; 95% CI, 0.58 to 1.46). In patients with acute basilar artery occlusion, no significant gender differences for outcome and recanalization were observed, regardless of treatment modality
U2 - https://doi.org/10.1161/STROKEAHA.110.594036
DO - https://doi.org/10.1161/STROKEAHA.110.594036
M3 - Article
C2 - 20947845
SN - 0039-2499
VL - 41
SP - 2693
EP - 2696
JO - Stroke; a journal of cerebral circulation
JF - Stroke; a journal of cerebral circulation
IS - 11
ER -