Acute effects of interferon-alpha administration on testosterone concentrations in healthy men

E. P. Corssmit; E. Endert; H. P. Sauerwein; J. A. Romijn

doi:https://doi.org/10.1530/eje.0.1430371

Acute effects of interferon-alpha administration on testosterone concentrations in healthy men

E. P. Corssmit, E. Endert, H. P. Sauerwein, J. A. Romijn

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Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Recombinant human interferon alpha (rhIFN-alpha) is used therapeutically in malignant disorders and chronic hepatitis. The present study was assessed to study the effects of rhIFN-alpha on the hypothalamic-pituitary-testicular (HPT) axis. We performed a saline-controlled cross-over study in six healthy men, sequentially measuring the serum concentrations of gonadotropins, testosterone, the free androgen index (FAI) and sex hormone-binding globulin (SHBG) after a bolus subcutaneous injection of rhIFN-alpha. rhIFN-alpha induced a sustained decrease of both testosterone (from 19.5+/-1.88 to a nadir of 5.49+/-0.51nmol/l at the end of the study) and FAI (from 98.7+/-14.7 to a nadir of 32. 1+/-5.3 at the end of the study), whereas concentrations of LH, FSH and SHBG were not different between the two studies. Our results suggest that rhIFN-alpha affects the HPT axis at the testicular level, either directly or indirectly, and changes feedback relationships between the pituitary and the testis

Original language	English
Pages (from-to)	371-374
Journal	European journal of endocrinology / European Federation of Endocrine Societies
Volume	143
Issue number	3
DOIs	https://doi.org/10.1530/eje.0.1430371
Publication status	Published - 2000

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https://doi.org/10.1530/eje.0.1430371

Cite this

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title = "Acute effects of interferon-alpha administration on testosterone concentrations in healthy men",

abstract = "Recombinant human interferon alpha (rhIFN-alpha) is used therapeutically in malignant disorders and chronic hepatitis. The present study was assessed to study the effects of rhIFN-alpha on the hypothalamic-pituitary-testicular (HPT) axis. We performed a saline-controlled cross-over study in six healthy men, sequentially measuring the serum concentrations of gonadotropins, testosterone, the free androgen index (FAI) and sex hormone-binding globulin (SHBG) after a bolus subcutaneous injection of rhIFN-alpha. rhIFN-alpha induced a sustained decrease of both testosterone (from 19.5+/-1.88 to a nadir of 5.49+/-0.51nmol/l at the end of the study) and FAI (from 98.7+/-14.7 to a nadir of 32. 1+/-5.3 at the end of the study), whereas concentrations of LH, FSH and SHBG were not different between the two studies. Our results suggest that rhIFN-alpha affects the HPT axis at the testicular level, either directly or indirectly, and changes feedback relationships between the pituitary and the testis",

author = "Corssmit, {E. P.} and E. Endert and Sauerwein, {H. P.} and Romijn, {J. A.}",

year = "2000",

doi = "https://doi.org/10.1530/eje.0.1430371",

language = "English",

volume = "143",

pages = "371--374",

journal = "European journal of endocrinology / European Federation of Endocrine Societies",

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publisher = "BioScientifica Ltd.",

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TY - JOUR

T1 - Acute effects of interferon-alpha administration on testosterone concentrations in healthy men

AU - Corssmit, E. P.

AU - Endert, E.

AU - Sauerwein, H. P.

AU - Romijn, J. A.

PY - 2000

Y1 - 2000

N2 - Recombinant human interferon alpha (rhIFN-alpha) is used therapeutically in malignant disorders and chronic hepatitis. The present study was assessed to study the effects of rhIFN-alpha on the hypothalamic-pituitary-testicular (HPT) axis. We performed a saline-controlled cross-over study in six healthy men, sequentially measuring the serum concentrations of gonadotropins, testosterone, the free androgen index (FAI) and sex hormone-binding globulin (SHBG) after a bolus subcutaneous injection of rhIFN-alpha. rhIFN-alpha induced a sustained decrease of both testosterone (from 19.5+/-1.88 to a nadir of 5.49+/-0.51nmol/l at the end of the study) and FAI (from 98.7+/-14.7 to a nadir of 32. 1+/-5.3 at the end of the study), whereas concentrations of LH, FSH and SHBG were not different between the two studies. Our results suggest that rhIFN-alpha affects the HPT axis at the testicular level, either directly or indirectly, and changes feedback relationships between the pituitary and the testis

AB - Recombinant human interferon alpha (rhIFN-alpha) is used therapeutically in malignant disorders and chronic hepatitis. The present study was assessed to study the effects of rhIFN-alpha on the hypothalamic-pituitary-testicular (HPT) axis. We performed a saline-controlled cross-over study in six healthy men, sequentially measuring the serum concentrations of gonadotropins, testosterone, the free androgen index (FAI) and sex hormone-binding globulin (SHBG) after a bolus subcutaneous injection of rhIFN-alpha. rhIFN-alpha induced a sustained decrease of both testosterone (from 19.5+/-1.88 to a nadir of 5.49+/-0.51nmol/l at the end of the study) and FAI (from 98.7+/-14.7 to a nadir of 32. 1+/-5.3 at the end of the study), whereas concentrations of LH, FSH and SHBG were not different between the two studies. Our results suggest that rhIFN-alpha affects the HPT axis at the testicular level, either directly or indirectly, and changes feedback relationships between the pituitary and the testis

U2 - https://doi.org/10.1530/eje.0.1430371

DO - https://doi.org/10.1530/eje.0.1430371

M3 - Article

C2 - 11022179

SN - 0804-4643

VL - 143

SP - 371

EP - 374

JO - European journal of endocrinology / European Federation of Endocrine Societies

JF - European journal of endocrinology / European Federation of Endocrine Societies

IS - 3

ER -