TY - JOUR
T1 - Limited Clinical Impact of Ultralow-Dose Computed Tomography in Suspected Community-Acquired Pneumonia
AU - van Engelen, Tjitske S. R.
AU - Kanglie, Maadrika M. N. P.
AU - van den Berk, Inge A. H.
AU - Altenburg, Josje
AU - Dijkgraaf, Marcel G. W.
AU - Bossuyt, Patrick M. M.
AU - Stoker, Jaap
AU - Prins, Jan M.
AU - OPTIMACT study group
AU - Annema, Jouke
AU - Bbeenen, Ludo F. M.
AU - Bekebrede-Kaufman, Dominique
AU - van den Berg, Joost W.
AU - Moens, Sophie J. Bernelot
AU - Bipat, Shandra
AU - Boerrigter, Bart G.
AU - Bomers, Marije M. K.
AU - van den Boogert, Marjolein A. W.
AU - Bouwman, Merel L. J.
AU - Bresser, Paul
AU - van den Broek, Annemieke K.
AU - Elzer, Brenda
AU - Donkers, Jos
AU - Eryigit, Elvin
AU - Frankemölle, Betty
AU - Groeneveld, Nina-Suzanne
AU - Groenink, Maarten
AU - Halsema, Emo E. Van
AU - Begemann, Naomi M. Haverkamp
AU - Höchheimer, Suzanne M. R.
AU - Hoff, David Ten
AU - Holleman, Frits
AU - Hoolwerf, Erwin
AU - Hulzebosch, Dorine
AU - Keijzers, Mitran
AU - Kolkman, Saskia
AU - Kooter, Jos A. J.
AU - Korevaar, Daniel A.
AU - van der Lee, Ivo
AU - Leenhouts, Peter A.
AU - Luijendijk, Paul
AU - Mol, Bregje
AU - Luitse, Jan
AU - Meijboom, Lilian J.
AU - Pijning, Anna
AU - van der Poll, Tom
AU - Reijnders, Tom D. Y.
AU - Ridderikhof, Milan L.
AU - Romijn, Johannes A.
AU - Sprengers, Ralf W.
AU - Westerhof, Guus A.
AU - Monraats, Melanie A.
AU - Middeldorp, Saskia
AU - Scheerder, Maeke J.
AU - Schoonderwoerd, Antoinet J. N.
AU - Schijf, Laura J.
AU - Smithuis, Frank F.
AU - Streekstra, Geert J.
AU - Vogel, Maaike J. A.
AU - Vuurboom, Mart
AU - Wijsman, Pieta C.
AU - Winter, Michiel M.
AU - Wouda, Rosa D.
N1 - Funding Information: Financial support. This work was supported by an innovation grant from the Amsterdam UMC, location Academic Medical Center (AMC), University of Amsterdam (to MMNPK, IAHvdB, and JS), and a Health Care Efficiency Program grant from the Netherlands Organization for Health Research and Development ([ZonMW] 843001806; to MMNPK, IAHvdB, and JS). Funding Information: Potential conflicts of interest. TSRvE reports personal fees (a PhD Scholarship grant) from Amsterdam UMC. MMNPK, IAHvdB, and JS received an innovation grant from the Amsterdam UMC, location AMC, University of Amsterdam, and a grant from the Health Care Efficiency Program of the Netherlands Organization for Health Research and Development (ZonMW). Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. Publisher Copyright: © 2023 The Author(s). Published by Oxford University Press on behalf of Infectious Diseases Society of America.
PY - 2023/5/1
Y1 - 2023/5/1
N2 - Patients clinically suspected of community-acquired pneumonia (CAP) were randomized between ultralow-dose chest computed tomography ([ULDCT] 261 patients) and chest radiograph ([CXR] 231 patients). We did not find evidence that performing ULDCT instead of CXR affects antibiotic treatment policy or patient outcomes. However, in a subgroup of afebrile patients, there were more patients diagnosed with CAP in the ULDCT group (ULDCT, 106 of 608 patients; CXR, 71 of 654 patients; P =. 001).
AB - Patients clinically suspected of community-acquired pneumonia (CAP) were randomized between ultralow-dose chest computed tomography ([ULDCT] 261 patients) and chest radiograph ([CXR] 231 patients). We did not find evidence that performing ULDCT instead of CXR affects antibiotic treatment policy or patient outcomes. However, in a subgroup of afebrile patients, there were more patients diagnosed with CAP in the ULDCT group (ULDCT, 106 of 608 patients; CXR, 71 of 654 patients; P =. 001).
KW - adult
KW - clinical decision making
KW - emergency service
KW - pneumonia
KW - radiography
UR - http://www.scopus.com/inward/record.url?scp=85160746068&partnerID=8YFLogxK
U2 - https://doi.org/10.1093/ofid/ofad215
DO - https://doi.org/10.1093/ofid/ofad215
M3 - Article
C2 - 37213423
SN - 2328-8957
VL - 10
JO - Open forum infectious diseases
JF - Open forum infectious diseases
IS - 5
M1 - ofad215
ER -