TY - JOUR
T1 - Adipokines in multiple sclerosis patients are related to clinical and radiological measures
AU - Loonstra, Floor C
AU - Falize, Kim F
AU - de Ruiter, Lodewijk R J
AU - Schoonheim, Menno M
AU - Strijbis, Eva M M
AU - Killestein, Joep
AU - de Vries, Helga E
AU - Uitdehaag, Bernard M J
AU - Rijnsburger, Merel
N1 - Funding Information: This study was supported by the VriendenLoterij, Dutch MS Research Foundation, Mission Summit, VUmc Foundation. Furthermore, this work was funded by a grant from GMSI (Grant for Multiple Sclerosis Innovation), an initiative by the healthcare business of Merck KGaA, Darmstadt, Germany (CrossRef Funder ID: 10.13039/100009945) to support research addressing unmet needs for MS. Publisher Copyright: © 2022, The Author(s).
PY - 2022/12/23
Y1 - 2022/12/23
N2 - BACKGROUND: An imbalance of adipokines, hormones secreted by white adipose tissue, is suggested to play a role in the immunopathology of multiple sclerosis (MS). In people with MS (PwMS) of the same age, we aimed to determine whether the adipokines adiponectin, leptin, and resistin are associated with MS disease severity. Furthermore, we aimed to investigate whether these adipokines mediate the association between body mass index (BMI) and MS disease severity.METHODS: Adiponectin, resistin, and leptin were determined in serum using ELISA. 288 PwMS and 125 healthy controls (HC) were included from the Project Y cohort, a population-based cross-sectional study of people with MS born in the Netherlands in 1966, and age and sex-matched HC. Adipokine levels and BMI were related to demographic, clinical and disability measures, and MRI-based brain volumes.RESULTS: Adiponectin levels were 1.2 fold higher in PwMS vs. HC, especially in secondary progressive MS. Furthermore, we found a sex-specific increase in adiponectin levels in primary progressive (PP) male patients compared to male controls. Leptin and resistin levels did not differ between PwMS and HC, however, leptin levels were associated with higher disability (EDSS) and resistin strongly related to brain volumes in progressive patients, especially in several grey matter regions in PPMS. Importantly, correction for BMI did not significantly change the results.CONCLUSION: In PwMS of the same age, we found associations between adipokines (adiponectin, leptin, and resistin) and a range of clinical and radiological metrics. These associations were independent of BMI, indicating distinct mechanisms.
AB - BACKGROUND: An imbalance of adipokines, hormones secreted by white adipose tissue, is suggested to play a role in the immunopathology of multiple sclerosis (MS). In people with MS (PwMS) of the same age, we aimed to determine whether the adipokines adiponectin, leptin, and resistin are associated with MS disease severity. Furthermore, we aimed to investigate whether these adipokines mediate the association between body mass index (BMI) and MS disease severity.METHODS: Adiponectin, resistin, and leptin were determined in serum using ELISA. 288 PwMS and 125 healthy controls (HC) were included from the Project Y cohort, a population-based cross-sectional study of people with MS born in the Netherlands in 1966, and age and sex-matched HC. Adipokine levels and BMI were related to demographic, clinical and disability measures, and MRI-based brain volumes.RESULTS: Adiponectin levels were 1.2 fold higher in PwMS vs. HC, especially in secondary progressive MS. Furthermore, we found a sex-specific increase in adiponectin levels in primary progressive (PP) male patients compared to male controls. Leptin and resistin levels did not differ between PwMS and HC, however, leptin levels were associated with higher disability (EDSS) and resistin strongly related to brain volumes in progressive patients, especially in several grey matter regions in PPMS. Importantly, correction for BMI did not significantly change the results.CONCLUSION: In PwMS of the same age, we found associations between adipokines (adiponectin, leptin, and resistin) and a range of clinical and radiological metrics. These associations were independent of BMI, indicating distinct mechanisms.
KW - Adipokines
KW - BMI MRI
KW - Disability
KW - Multiple sclerosis
UR - http://www.scopus.com/inward/record.url?scp=85144705467&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/s00415-022-11519-8
DO - https://doi.org/10.1007/s00415-022-11519-8
M3 - Article
C2 - 36562851
SN - 0340-5354
JO - Journal of neurology
JF - Journal of neurology
ER -