Adrenergic β2 receptor activation stimulates anti-inflammatory properties of dendritic cells in vitro

Laurens E. Nijhuis, Brenda J. Olivier, Shobit Dhawan, Francisca W. Hilbers, Louis Boon, Monika C. Wolkers, Janneke N. Samsom, Wouter J. de Jonge

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66 Citations (Scopus)

Abstract

Vagal nerve efferent activation has been shown to ameliorate the course of many inflammatory disease states. This neuro-modulatory effect has been suggested to rest on acetylcholine receptor (AChR) activation on tissue macrophages or dendritic cells (DCs). In more recent studies, vagal anti-inflammatory activity was shown involve adrenergic, splenic, pathways. Here we provide evidence that the adrenergic, rather than cholinergic, receptor activation on bone marrow derived DCs results in enhanced endocytosis uptake, enhanced IL-10 production but a decreased IL-6, IL-12p70 and IL-23 production. In antigen specific T cell stimulation assays, adrenergic β2 receptor activation on bone marrow DCs led to an enhanced potential to induce Foxp3 positive suppressive Treg cells. These effects were independent of IL10-R activation, TGFβ release, or retinoic acid (RA) secretion. Hence, adrenergic receptor β2 activation modulates DC function resulting in skewing towards anti-inflammatory T cell phenotypes
Original languageEnglish
Pages (from-to)e85086
JournalPLOS ONE
Volume9
Issue number1
DOIs
Publication statusPublished - 2014

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