TY - JOUR
T1 - Age and functional relevance of coronary stenosis
T2 - a post hoc analysis of the ADVISE II trial
AU - Faria, Daniel Candeias
AU - Lee, Joo Myung
AU - van der Hoef, Tim
AU - Mejía-Rentería, Hernán
AU - Echavarría-Pinto, Mauro
AU - Baptista, S. rgio Bravo
AU - Cerrato, Enrico
AU - Garcia-Garcia, Hector M.
AU - Davies, Justin
AU - Onuma, Yoshinobu
AU - Samady, Habib
AU - Piek, Jan J.
AU - Serruys, Patrick W.
AU - Lerman, Amir
AU - Escaned, Javier
N1 - Funding Information: The ADVISE II study was funded by Volcano Corporation and all analysis was independently performed by the core laboratory (Cardialysis). The authors of this study are solely responsible for the design and conduct, all analysis, manuscript drafting and editing, and are responsible for its final contents. Publisher Copyright: © Europa Digital & Publishing 2021. All rights reserved.
PY - 2021/10/20
Y1 - 2021/10/20
N2 - BACKGROUND: The influence of age-dependent changes on fractional flow reserve (FFR) or instantaneous wave-free ratio (iFR) and the response to pharmacological hyperaemia has not been investigated. AIMS: We investigated the impact of age on these indices. METHODS: This is a post hoc analysis of the ADVISE II trial, including a total of 690 pressure recordings (in 591 patients). Age-dependent correlations with FFR and iFR were calculated and adjusted for stenosis severity. Patients were stratified into three age terciles. The hyperaemic response to adenosine, calculated as the difference between resting and hyperaemic pressure ratios, and the prevalence of FFR-iFR discordance were assessed. RESULTS: Age correlated positively with FFR (r=0.08, 95% CI: 0.01 to 0.15, p=0.015), but not with iFR (r=-0.03, 95% CI: -0.11 to 0.04, p=0.411). The hyperaemic response to adenosine decreased with patient age (0.12±0.07, 0.11±0.06, 0.09±0.05, for the 1st [33-58 years], 2nd [59-69 years] and 3rd [70-94 years] age tertiles, respectively, p<0.001) and showed significant correlation with age (r=-0.14, 95% CI: -0.21 to -0.06, p<0.001). The proportion of patients with FFR ≤0.80+iFR >0.89 discordance doubled in the first age tercile (14.1% vs 7.1% vs 7.0%, p=0.005). CONCLUSIONS: The hyperaemic response of the microcirculation to adenosine administration is age dependent. FFR values increase with patient age, while iFR values remain constant across the age spectrum. These findings contribute to explaining differences observed in functional stenosis classification with hyperaemic and non-hyperaemic coronary indices.
AB - BACKGROUND: The influence of age-dependent changes on fractional flow reserve (FFR) or instantaneous wave-free ratio (iFR) and the response to pharmacological hyperaemia has not been investigated. AIMS: We investigated the impact of age on these indices. METHODS: This is a post hoc analysis of the ADVISE II trial, including a total of 690 pressure recordings (in 591 patients). Age-dependent correlations with FFR and iFR were calculated and adjusted for stenosis severity. Patients were stratified into three age terciles. The hyperaemic response to adenosine, calculated as the difference between resting and hyperaemic pressure ratios, and the prevalence of FFR-iFR discordance were assessed. RESULTS: Age correlated positively with FFR (r=0.08, 95% CI: 0.01 to 0.15, p=0.015), but not with iFR (r=-0.03, 95% CI: -0.11 to 0.04, p=0.411). The hyperaemic response to adenosine decreased with patient age (0.12±0.07, 0.11±0.06, 0.09±0.05, for the 1st [33-58 years], 2nd [59-69 years] and 3rd [70-94 years] age tertiles, respectively, p<0.001) and showed significant correlation with age (r=-0.14, 95% CI: -0.21 to -0.06, p<0.001). The proportion of patients with FFR ≤0.80+iFR >0.89 discordance doubled in the first age tercile (14.1% vs 7.1% vs 7.0%, p=0.005). CONCLUSIONS: The hyperaemic response of the microcirculation to adenosine administration is age dependent. FFR values increase with patient age, while iFR values remain constant across the age spectrum. These findings contribute to explaining differences observed in functional stenosis classification with hyperaemic and non-hyperaemic coronary indices.
KW - ACS/NSTE-ACS
KW - Fractional flow reserve
KW - Stable angina
UR - http://www.scopus.com/inward/record.url?scp=85119457984&partnerID=8YFLogxK
U2 - https://doi.org/10.4244/EIJ-D-20-01163
DO - https://doi.org/10.4244/EIJ-D-20-01163
M3 - Article
C2 - 33720019
SN - 1774-024X
VL - 17
SP - 757
EP - 764
JO - Eurointervention
JF - Eurointervention
IS - 9
ER -