TY - JOUR
T1 - Age-Dependent Differences in Postprandial Bile-Acid Metabolism and the Role of the Gut Microbiome
AU - Majait, Soumia
AU - Meessen, Emma C. E.
AU - Davids, Mark
AU - Chahid, Youssef
AU - Olde Damink, Steven W.
AU - Schaap, Frank G.
AU - Kemper, Ellis Marleen
AU - Nieuwdorp, Max
AU - Soeters, Maarten R.
N1 - Publisher Copyright: © 2024 by the authors.
PY - 2024/4/1
Y1 - 2024/4/1
N2 - Ageing changes the impact of nutrition, whereby inflammation has been suggested to play a role in age-related disabilities such as diabetes and cardiovascular disease. The aim of this study was to investigate differences in postprandial bile-acid response and its effect on energy metabolism between young and elderly people. Nine young, healthy men and nine elderly, healthy men underwent a liquid mixed-meal test. Postprandial bile-acid levels, insulin, glucose, GLP-1, C4, FGF19 and lipids were measured. Appetite, body composition, energy expenditure and gut microbiome were also measured. The elderly population showed lower glycine conjugated CDCA and UDCA levels and higher abundances of Ruminiclostridium, Marvinbryantia and Catenibacterium, but lower food intake, decreased fat free mass and increased cholesterol levels. Aging is associated with changes in postprandial bile-acid composition and microbiome, diminished hunger and changes in body composition and lipid levels. Further studies are needed to determine if these changes may contribute to malnutrition and sarcopenia in elderly.
AB - Ageing changes the impact of nutrition, whereby inflammation has been suggested to play a role in age-related disabilities such as diabetes and cardiovascular disease. The aim of this study was to investigate differences in postprandial bile-acid response and its effect on energy metabolism between young and elderly people. Nine young, healthy men and nine elderly, healthy men underwent a liquid mixed-meal test. Postprandial bile-acid levels, insulin, glucose, GLP-1, C4, FGF19 and lipids were measured. Appetite, body composition, energy expenditure and gut microbiome were also measured. The elderly population showed lower glycine conjugated CDCA and UDCA levels and higher abundances of Ruminiclostridium, Marvinbryantia and Catenibacterium, but lower food intake, decreased fat free mass and increased cholesterol levels. Aging is associated with changes in postprandial bile-acid composition and microbiome, diminished hunger and changes in body composition and lipid levels. Further studies are needed to determine if these changes may contribute to malnutrition and sarcopenia in elderly.
KW - anorexia of aging
KW - bile acids
KW - insulin resistance
KW - malnutrition
KW - postprandial
KW - sarcopenia
UR - http://www.scopus.com/inward/record.url?scp=85191421973&partnerID=8YFLogxK
U2 - 10.3390/microorganisms12040764
DO - 10.3390/microorganisms12040764
M3 - Article
C2 - 38674708
SN - 2076-2607
VL - 12
JO - Microorganisms
JF - Microorganisms
IS - 4
M1 - 764
ER -