Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms

Roderick C. Slieker; Maarten van Iterson; Rene Luijk; Marian Beekman; Daria V. Zhernakova; Matthijs H. Moed; Hailiang Mei; Michiel van Galen; Patrick Deelen; Marc Jan Bonder; Alexandra Zhernakova; Andre G. Uitterlinden; Ettje F. Tigchelaar; Coen D. A. Stehouwer; Casper G. Schalkwijk; Carla J. H. van der Kallen; Albert Hofman; Diana van Heemst; Eco J. de Geus; Jenny van Dongen; Joris Deelen; Leonard H. van den Berg; Joyce van Meurs; Rick Jansen; Peter A. C. 't Hoen; Lude Franke; Cisca Wijmenga; Jan H. Veldink; Morris A. Swertz; Marleen M. J. van Greevenbroek; Cornelia M. van Duijn; Dorret I. Boomsma; P. Eline Slagboom; Bastiaan T. Heijmans

doi:https://doi.org/10.1186/s13059-016-1053-6

Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms

Roderick C. Slieker, Maarten van Iterson, Rene Luijk, Marian Beekman, Daria V. Zhernakova, Matthijs H. Moed, Hailiang Mei, Michiel van Galen, Patrick Deelen, Marc Jan Bonder, Alexandra Zhernakova, Andre G. Uitterlinden, Ettje F. Tigchelaar, Coen D. A. Stehouwer, Casper G. Schalkwijk, Carla J. H. van der Kallen, Albert Hofman, Diana van Heemst, Eco J. de Geus, Jenny van DongenJoris Deelen, Leonard H. van den Berg, Joyce van Meurs, Rick Jansen, Peter A. C. 't Hoen, Lude Franke, Cisca Wijmenga, Jan H. Veldink, Morris A. Swertz, Marleen M. J. van Greevenbroek, Cornelia M. van Duijn, Dorret I. Boomsma, P. Eline Slagboom, Bastiaan T. Heijmans

Research output: Contribution to journal › Article › Academic › peer-review

96 Citations (Scopus)

Original language	English
Pages (from-to)	1-13
Journal	Genome biology
Volume	17
Issue number	191
DOIs	https://doi.org/10.1186/s13059-016-1053-6
Publication status	Published - 22 Sept 2016

Keywords

450k
Ageing
DNA damage
DNA methylation
Variability

Access to Document

https://doi.org/10.1186/s13059-016-1053-6

Cite this

Slieker, R. C., van Iterson, M., Luijk, R., Beekman, M., Zhernakova, D. V., Moed, M. H., Mei, H., van Galen, M., Deelen, P., Bonder, M. J., Zhernakova, A., Uitterlinden, A. G., Tigchelaar, E. F., Stehouwer, C. D. A., Schalkwijk, C. G., van der Kallen, C. J. H., Hofman, A., van Heemst, D., de Geus, E. J., ... Heijmans, B. T. (2016). Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms. Genome biology, 17(191), 1-13. https://doi.org/10.1186/s13059-016-1053-6

@article{8bebbbd2c2684d25bf732d71e17f1940,

title = "Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms",

keywords = "450k, Ageing, DNA damage, DNA methylation, Variability",

author = "Slieker, {Roderick C.} and {van Iterson}, Maarten and Rene Luijk and Marian Beekman and Zhernakova, {Daria V.} and Moed, {Matthijs H.} and Hailiang Mei and {van Galen}, Michiel and Patrick Deelen and Bonder, {Marc Jan} and Alexandra Zhernakova and Uitterlinden, {Andre G.} and Tigchelaar, {Ettje F.} and Stehouwer, {Coen D. A.} and Schalkwijk, {Casper G.} and {van der Kallen}, {Carla J. H.} and Albert Hofman and {van Heemst}, Diana and {de Geus}, {Eco J.} and {van Dongen}, Jenny and Joris Deelen and {van den Berg}, {Leonard H.} and {van Meurs}, Joyce and Rick Jansen and {'t Hoen}, {Peter A. C.} and Lude Franke and Cisca Wijmenga and Veldink, {Jan H.} and Swertz, {Morris A.} and {van Greevenbroek}, {Marleen M. J.} and {van Duijn}, {Cornelia M.} and Boomsma, {Dorret I.} and Slagboom, {P. Eline} and Heijmans, {Bastiaan T.}",

year = "2016",

month = sep,

day = "22",

doi = "https://doi.org/10.1186/s13059-016-1053-6",

language = "English",

volume = "17",

pages = "1--13",

journal = "Genome Biol",

issn = "1465-6906",

publisher = "BioMed Central",

number = "191",

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Slieker, RC, van Iterson, M, Luijk, R, Beekman, M, Zhernakova, DV, Moed, MH, Mei, H, van Galen, M, Deelen, P, Bonder, MJ, Zhernakova, A, Uitterlinden, AG, Tigchelaar, EF, Stehouwer, CDA, Schalkwijk, CG, van der Kallen, CJH, Hofman, A, van Heemst, D, de Geus, EJ, van Dongen, J, Deelen, J, van den Berg, LH, van Meurs, J, Jansen, R, 't Hoen, PAC, Franke, L, Wijmenga, C, Veldink, JH, Swertz, MA, van Greevenbroek, MMJ, van Duijn, CM, Boomsma, DI, Slagboom, PE & Heijmans, BT 2016, 'Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms', Genome biology, vol. 17, no. 191, pp. 1-13. https://doi.org/10.1186/s13059-016-1053-6

TY - JOUR

T1 - Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms

AU - Slieker, Roderick C.

AU - van Iterson, Maarten

AU - Luijk, Rene

AU - Beekman, Marian

AU - Zhernakova, Daria V.

AU - Moed, Matthijs H.

AU - Mei, Hailiang

AU - van Galen, Michiel

AU - Deelen, Patrick

AU - Bonder, Marc Jan

AU - Zhernakova, Alexandra

AU - Uitterlinden, Andre G.

AU - Tigchelaar, Ettje F.

AU - Stehouwer, Coen D. A.

AU - Schalkwijk, Casper G.

AU - van der Kallen, Carla J. H.

AU - Hofman, Albert

AU - van Heemst, Diana

AU - de Geus, Eco J.

AU - van Dongen, Jenny

AU - Deelen, Joris

AU - van den Berg, Leonard H.

AU - van Meurs, Joyce

AU - Jansen, Rick

AU - 't Hoen, Peter A. C.

AU - Franke, Lude

AU - Wijmenga, Cisca

AU - Veldink, Jan H.

AU - Swertz, Morris A.

AU - van Greevenbroek, Marleen M. J.

AU - van Duijn, Cornelia M.

AU - Boomsma, Dorret I.

AU - Slagboom, P. Eline

AU - Heijmans, Bastiaan T.

PY - 2016/9/22

Y1 - 2016/9/22

KW - 450k

KW - Ageing

KW - DNA damage

KW - DNA methylation

KW - Variability

U2 - https://doi.org/10.1186/s13059-016-1053-6

DO - https://doi.org/10.1186/s13059-016-1053-6

M3 - Article

C2 - 27654999

SN - 1465-6906

VL - 17

SP - 1

EP - 13

JO - Genome Biol

JF - Genome Biol

IS - 191

ER -