Aging selectively dampens oscillation of lipid abundance in white and brown adipose tissue

Ntsiki M. Held; M. Renate Buijink; Hyung L. Elfrink; Sander Kooijman; Georges E. Janssens; Angela C. M. Luyf; Mia L. Pras-Raves; Frédéric M. Vaz; Stephan Michel; Riekelt H. Houtkooper; Michel van Weeghel

doi:https://doi.org/10.1038/s41598-021-85455-4

Aging selectively dampens oscillation of lipid abundance in white and brown adipose tissue

Ntsiki M. Held, M. Renate Buijink, Hyung L. Elfrink, Sander Kooijman, Georges E. Janssens, Angela C. M. Luyf, Mia L. Pras-Raves, Frédéric M. Vaz, Stephan Michel, Riekelt H. Houtkooper, Michel van Weeghel

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Abstract

Lipid metabolism is under the control of the circadian system and circadian dysregulation has been linked to obesity and dyslipidemia. These factors and outcomes have also been associated to, or affected by, the process of aging. Here, we investigated whether murine white (WAT) and brown (BAT) adipose tissue lipids exhibit rhythmicity and if this is affected by aging. To this end, we have measured the 24 h lipid profiles of WAT and BAT using a global lipidomics analysis of > 1100 lipids. We observed rhythmicity in nearly all lipid classes including glycerolipids, glycerophospholipids, sterol lipids and sphingolipids. Overall, ~ 22% of the analyzed lipids were considered rhythmic in WAT and BAT. Despite a general accumulation of lipids upon aging the fraction of oscillating lipids decreased in both tissues to 14% and 18%, respectively. Diurnal profiles of lipids in BAT appeared to depend on the lipid acyl chain length and this specific regulation was lost in aged mice. Our study revealed how aging affects the rhythmicity of lipid metabolism and could contribute to the quest for targets that improve diurnal lipid homeostasis to maintain cardiometabolic health during aging.

Original language	English
Article number	5932
Pages (from-to)	5932
Journal	Scientific reports
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41598-021-85455-4 https://doi.org/10.1038/s41598-021-85455-4
Publication status	Published - 1 Dec 2021

Keywords

Adipose Tissue, Brown/metabolism
Adipose Tissue, White/metabolism
Age Factors
Aging/metabolism
Animals
Biomarkers
Chromatography, High Pressure Liquid
Computational Biology/methods
Lipid Metabolism
Lipidomics/methods
Male
Mass Spectrometry
Mice

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Held, N. M., Buijink, M. R., Elfrink, H. L., Kooijman, S., Janssens, G. E., Luyf, A. C. M., Pras-Raves, M. L., Vaz, F. M., Michel, S., Houtkooper, R. H., & van Weeghel, M. (2021). Aging selectively dampens oscillation of lipid abundance in white and brown adipose tissue. Scientific reports, 11(1), 5932. Article 5932. https://doi.org/10.1038/s41598-021-85455-4, https://doi.org/10.1038/s41598-021-85455-4

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title = "Aging selectively dampens oscillation of lipid abundance in white and brown adipose tissue",

abstract = "Lipid metabolism is under the control of the circadian system and circadian dysregulation has been linked to obesity and dyslipidemia. These factors and outcomes have also been associated to, or affected by, the process of aging. Here, we investigated whether murine white (WAT) and brown (BAT) adipose tissue lipids exhibit rhythmicity and if this is affected by aging. To this end, we have measured the 24 h lipid profiles of WAT and BAT using a global lipidomics analysis of > 1100 lipids. We observed rhythmicity in nearly all lipid classes including glycerolipids, glycerophospholipids, sterol lipids and sphingolipids. Overall, ~ 22% of the analyzed lipids were considered rhythmic in WAT and BAT. Despite a general accumulation of lipids upon aging the fraction of oscillating lipids decreased in both tissues to 14% and 18%, respectively. Diurnal profiles of lipids in BAT appeared to depend on the lipid acyl chain length and this specific regulation was lost in aged mice. Our study revealed how aging affects the rhythmicity of lipid metabolism and could contribute to the quest for targets that improve diurnal lipid homeostasis to maintain cardiometabolic health during aging.",

keywords = "Adipose Tissue, Brown/metabolism, Adipose Tissue, White/metabolism, Age Factors, Aging/metabolism, Animals, Biomarkers, Chromatography, High Pressure Liquid, Computational Biology/methods, Lipid Metabolism, Lipidomics/methods, Male, Mass Spectrometry, Mice",

author = "Held, {Ntsiki M.} and Buijink, {M. Renate} and Elfrink, {Hyung L.} and Sander Kooijman and Janssens, {Georges E.} and Luyf, {Angela C. M.} and Pras-Raves, {Mia L.} and Vaz, {Fr{\'e}d{\'e}ric M.} and Stephan Michel and Houtkooper, {Riekelt H.} and {van Weeghel}, Michel",

note = "Funding Information: This work is financially supported by Rembrandt Institute for Cardiovascular Science (to RHH) and The Netherlands Cardiovascular Research Initiative: an initiative with support of the Dutch Heart Foundation (CVON2014-02 ENERGISE). SK is funded by the Dutch Heart Foundation (2017T016), GEJ is supported by a VENI Grant from ZonMw (no. 09150161810014). RHH is funded by an ERC Starting Grant (no. 638290) and a ZonMw VIDI Grant (no. 917.15.305). Publisher Copyright: {\textcopyright} 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

month = dec,

day = "1",

doi = "https://doi.org/10.1038/s41598-021-85455-4",

language = "English",

volume = "11",

pages = "5932",

journal = "Scientific reports",

issn = "2045-2322",

publisher = "Springer Nature",

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Held, NM, Buijink, MR, Elfrink, HL, Kooijman, S, Janssens, GE, Luyf, ACM, Pras-Raves, ML , Vaz, FM, Michel, S, Houtkooper, RH & van Weeghel, M 2021, 'Aging selectively dampens oscillation of lipid abundance in white and brown adipose tissue', Scientific reports, vol. 11, no. 1, 5932, pp. 5932. https://doi.org/10.1038/s41598-021-85455-4, https://doi.org/10.1038/s41598-021-85455-4

TY - JOUR

T1 - Aging selectively dampens oscillation of lipid abundance in white and brown adipose tissue

AU - Held, Ntsiki M.

AU - Buijink, M. Renate

AU - Elfrink, Hyung L.

AU - Kooijman, Sander

AU - Janssens, Georges E.

AU - Luyf, Angela C. M.

AU - Pras-Raves, Mia L.

AU - Vaz, Frédéric M.

AU - Michel, Stephan

AU - Houtkooper, Riekelt H.

AU - van Weeghel, Michel

N1 - Funding Information: This work is financially supported by Rembrandt Institute for Cardiovascular Science (to RHH) and The Netherlands Cardiovascular Research Initiative: an initiative with support of the Dutch Heart Foundation (CVON2014-02 ENERGISE). SK is funded by the Dutch Heart Foundation (2017T016), GEJ is supported by a VENI Grant from ZonMw (no. 09150161810014). RHH is funded by an ERC Starting Grant (no. 638290) and a ZonMw VIDI Grant (no. 917.15.305). Publisher Copyright: © 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/12/1

Y1 - 2021/12/1

N2 - Lipid metabolism is under the control of the circadian system and circadian dysregulation has been linked to obesity and dyslipidemia. These factors and outcomes have also been associated to, or affected by, the process of aging. Here, we investigated whether murine white (WAT) and brown (BAT) adipose tissue lipids exhibit rhythmicity and if this is affected by aging. To this end, we have measured the 24 h lipid profiles of WAT and BAT using a global lipidomics analysis of > 1100 lipids. We observed rhythmicity in nearly all lipid classes including glycerolipids, glycerophospholipids, sterol lipids and sphingolipids. Overall, ~ 22% of the analyzed lipids were considered rhythmic in WAT and BAT. Despite a general accumulation of lipids upon aging the fraction of oscillating lipids decreased in both tissues to 14% and 18%, respectively. Diurnal profiles of lipids in BAT appeared to depend on the lipid acyl chain length and this specific regulation was lost in aged mice. Our study revealed how aging affects the rhythmicity of lipid metabolism and could contribute to the quest for targets that improve diurnal lipid homeostasis to maintain cardiometabolic health during aging.

AB - Lipid metabolism is under the control of the circadian system and circadian dysregulation has been linked to obesity and dyslipidemia. These factors and outcomes have also been associated to, or affected by, the process of aging. Here, we investigated whether murine white (WAT) and brown (BAT) adipose tissue lipids exhibit rhythmicity and if this is affected by aging. To this end, we have measured the 24 h lipid profiles of WAT and BAT using a global lipidomics analysis of > 1100 lipids. We observed rhythmicity in nearly all lipid classes including glycerolipids, glycerophospholipids, sterol lipids and sphingolipids. Overall, ~ 22% of the analyzed lipids were considered rhythmic in WAT and BAT. Despite a general accumulation of lipids upon aging the fraction of oscillating lipids decreased in both tissues to 14% and 18%, respectively. Diurnal profiles of lipids in BAT appeared to depend on the lipid acyl chain length and this specific regulation was lost in aged mice. Our study revealed how aging affects the rhythmicity of lipid metabolism and could contribute to the quest for targets that improve diurnal lipid homeostasis to maintain cardiometabolic health during aging.

KW - Adipose Tissue, Brown/metabolism

KW - Adipose Tissue, White/metabolism

KW - Age Factors

KW - Aging/metabolism

KW - Animals

KW - Biomarkers

KW - Chromatography, High Pressure Liquid

KW - Computational Biology/methods

KW - Lipid Metabolism

KW - Lipidomics/methods

KW - Male

KW - Mass Spectrometry

KW - Mice

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U2 - https://doi.org/10.1038/s41598-021-85455-4

DO - https://doi.org/10.1038/s41598-021-85455-4

M3 - Article

C2 - 33723320

SN - 2045-2322

VL - 11

SP - 5932

JO - Scientific reports

JF - Scientific reports

IS - 1

M1 - 5932

ER -

Aging selectively dampens oscillation of lipid abundance in white and brown adipose tissue

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Keywords

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