TY - JOUR
T1 - Albumin and Survival in Extremity Metastatic Bone Disease
T2 - An Analysis of Two Independent Datasets
AU - Thio, Quirina C. B. S.
AU - Karhade, Aditya V.
AU - Pham, Alicia
AU - Ogink, Paul T.
AU - Ferrone, Marco L.
AU - Schwab, Joseph H.
N1 - Publisher Copyright: © 2021 Taylor & Francis Group, LLC.
PY - 2021
Y1 - 2021
N2 - Introduction: Numerous prognostication models have been developed to estimate survival in patients with extremity metastatic bone disease, but few include albumin despite albumin’s role in malnutrition and inflammation. The purpose of this study was to examine two independent datasets to determine the value for albumin in prognosticating survival in this population. Materials and Methods: Extremity metastatic bone disease patients undergoing surgical management were identified from two independent populations. Population 1: Retrospective chart review at two tertiary care centers. Population 2: A large, national, North American multicenter surgical registry with 30-day follow-up. Bivariate and multivariate analyses were used to examine albumin’s value for prognostication at 1-, 3-, and 12-month after surgery. Results: In Population 1, 1,090 patients were identified with 1-, 3-, and 12-month mortality rates of 95 (8.8%), 305 (28.9%), and 639 (62.0%), respectively. In Population 2, 1,675 patients were identified with one-month postoperative mortality rates of 148 (8.8%). In both populations, hypoalbuminemia was an independent prognostic factor for mortality at 30 days. In the institutional set, hypoalbuminemia was additionally associated with 3- and 12-month mortality. Conclusions: Hypoalbuminemia is a marker for mortality in extremity metastatic bone disease. Further consideration of this marker could improve existing prognostication models in this population. Level of Evidence: III.
AB - Introduction: Numerous prognostication models have been developed to estimate survival in patients with extremity metastatic bone disease, but few include albumin despite albumin’s role in malnutrition and inflammation. The purpose of this study was to examine two independent datasets to determine the value for albumin in prognosticating survival in this population. Materials and Methods: Extremity metastatic bone disease patients undergoing surgical management were identified from two independent populations. Population 1: Retrospective chart review at two tertiary care centers. Population 2: A large, national, North American multicenter surgical registry with 30-day follow-up. Bivariate and multivariate analyses were used to examine albumin’s value for prognostication at 1-, 3-, and 12-month after surgery. Results: In Population 1, 1,090 patients were identified with 1-, 3-, and 12-month mortality rates of 95 (8.8%), 305 (28.9%), and 639 (62.0%), respectively. In Population 2, 1,675 patients were identified with one-month postoperative mortality rates of 148 (8.8%). In both populations, hypoalbuminemia was an independent prognostic factor for mortality at 30 days. In the institutional set, hypoalbuminemia was additionally associated with 3- and 12-month mortality. Conclusions: Hypoalbuminemia is a marker for mortality in extremity metastatic bone disease. Further consideration of this marker could improve existing prognostication models in this population. Level of Evidence: III.
UR - http://www.scopus.com/inward/record.url?scp=85115834171&partnerID=8YFLogxK
U2 - https://doi.org/10.1080/01635581.2021.1983614
DO - https://doi.org/10.1080/01635581.2021.1983614
M3 - Article
C2 - 34581215
SN - 0163-5581
JO - Nutrition and cancer
JF - Nutrition and cancer
ER -