TY - JOUR
T1 - Albumin synthesis rates in post-surgical infants and septic adolescents; influence of amino acids, energy, and insulin
AU - Verbruggen, Sascha C.
AU - Schierbeek, Henk
AU - Coss-Bu, Jorge
AU - Joosten, Koen F. M.
AU - Castillo, Leticia
AU - van Goudoever, Johannes B.
PY - 2011
Y1 - 2011
N2 - Background & aims: To investigate the effects of glucose, parenteral amino acids, and intravenous insulin on albumin synthesis rates in critically ill children. Methods: Two studies were performed in 8 post-surgical infants (age 9.8 +/- 1.9 months; weight 9.5 +/- 1.1 kg) and 9 septic adolescents (age 15 +/- 1 yr; BMI 23 +/- 4 kg m(-2)), respectively. All received a primed, constant, tracer infusion with [1-(13)C]Leucine. The infants in study 1 were randomized to receive low (2.5 mg kg(-1) min(-1)) and standard (5.0 mg kg(-1) min(-1)) glucose intake in a cross-over setting of two periods of 4 h each. The adolescents in study 2 were randomized to receive total parenteral nutrition with standard (1.5 g kg(-1) day(-1)) and high (3.0 g kg(-1) day(-1)) amino acid intake in a two day cross-over setting. On both study days, during the last 3 h of the tracer study, they received insulin infused at 80 mU m(-2) min(-1). Results: The post-surgical infants and the septic adolescents were mildly hypoalbuminemic (similar to 2.5 g dL(-1)) with high synthesis rates, which were not affected by different intakes of glucose, amino acids, or insulin infusion. Conclusions: Albumin synthesis rates in hypoalbuminemic critically ill children are high but were not upregulated through nutrient supply, and in septic adolescents are unaffected by insulin. (C) 2011 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved
AB - Background & aims: To investigate the effects of glucose, parenteral amino acids, and intravenous insulin on albumin synthesis rates in critically ill children. Methods: Two studies were performed in 8 post-surgical infants (age 9.8 +/- 1.9 months; weight 9.5 +/- 1.1 kg) and 9 septic adolescents (age 15 +/- 1 yr; BMI 23 +/- 4 kg m(-2)), respectively. All received a primed, constant, tracer infusion with [1-(13)C]Leucine. The infants in study 1 were randomized to receive low (2.5 mg kg(-1) min(-1)) and standard (5.0 mg kg(-1) min(-1)) glucose intake in a cross-over setting of two periods of 4 h each. The adolescents in study 2 were randomized to receive total parenteral nutrition with standard (1.5 g kg(-1) day(-1)) and high (3.0 g kg(-1) day(-1)) amino acid intake in a two day cross-over setting. On both study days, during the last 3 h of the tracer study, they received insulin infused at 80 mU m(-2) min(-1). Results: The post-surgical infants and the septic adolescents were mildly hypoalbuminemic (similar to 2.5 g dL(-1)) with high synthesis rates, which were not affected by different intakes of glucose, amino acids, or insulin infusion. Conclusions: Albumin synthesis rates in hypoalbuminemic critically ill children are high but were not upregulated through nutrient supply, and in septic adolescents are unaffected by insulin. (C) 2011 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved
U2 - https://doi.org/10.1016/j.clnu.2011.02.001
DO - https://doi.org/10.1016/j.clnu.2011.02.001
M3 - Article
C2 - 21367495
SN - 0261-5614
VL - 30
SP - 469
EP - 477
JO - Clinical nutrition (Edinburgh, Scotland)
JF - Clinical nutrition (Edinburgh, Scotland)
IS - 4
ER -