Allo-reactive tissue-resident T cells causing damage: An inside job

René A. W. van Lier; Pleun Hombrink

doi:https://doi.org/10.1084/jem.20220121

Allo-reactive tissue-resident T cells causing damage: An inside job

René A. W. van Lier, Pleun Hombrink

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Scopus)

Abstract

Tissue-resident memory T cells (TRM cells) reside in the epithelium and contribute to the first line defense against invading pathogens. Snyder et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20212059) now report that clonally expanded, recipient T cells persist as TRM cells in human lung allografts despite intensive immunosuppression. Their persistence may contribute to chronic allograft dysfunction.

Original language	English
Article number	e20220121
Journal	Journal of Experimental Medicine
Volume	219
Issue number	4
DOIs	https://doi.org/10.1084/jem.20220121
Publication status	Published - 4 Apr 2022
Externally published	Yes

Access to Document

https://doi.org/10.1084/jem.20220121

Cite this

@article{55aa3df7641c4c1da183a3a4a09e62c8,

title = "Allo-reactive tissue-resident T cells causing damage: An inside job",

abstract = "Tissue-resident memory T cells (TRM cells) reside in the epithelium and contribute to the first line defense against invading pathogens. Snyder et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20212059) now report that clonally expanded, recipient T cells persist as TRM cells in human lung allografts despite intensive immunosuppression. Their persistence may contribute to chronic allograft dysfunction.",

author = "{van Lier}, {Ren{\'e} A. W.} and Pleun Hombrink",

note = "Publisher Copyright: {\textcopyright} 2022 van Lier and Hombrink.",

year = "2022",

month = apr,

day = "4",

doi = "https://doi.org/10.1084/jem.20220121",

language = "English",

volume = "219",

journal = "Journal of Experimental Medicine",

issn = "0022-1007",

publisher = "Rockefeller University Press",

number = "4",

}

TY - JOUR

T1 - Allo-reactive tissue-resident T cells causing damage

T2 - An inside job

AU - van Lier, René A. W.

AU - Hombrink, Pleun

PY - 2022/4/4

Y1 - 2022/4/4

N2 - Tissue-resident memory T cells (TRM cells) reside in the epithelium and contribute to the first line defense against invading pathogens. Snyder et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20212059) now report that clonally expanded, recipient T cells persist as TRM cells in human lung allografts despite intensive immunosuppression. Their persistence may contribute to chronic allograft dysfunction.

AB - Tissue-resident memory T cells (TRM cells) reside in the epithelium and contribute to the first line defense against invading pathogens. Snyder et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20212059) now report that clonally expanded, recipient T cells persist as TRM cells in human lung allografts despite intensive immunosuppression. Their persistence may contribute to chronic allograft dysfunction.

UR - http://www.scopus.com/inward/record.url?scp=85126406907&partnerID=8YFLogxK

U2 - https://doi.org/10.1084/jem.20220121

DO - https://doi.org/10.1084/jem.20220121

M3 - Article

C2 - 35285872

SN - 0022-1007

VL - 219

JO - Journal of Experimental Medicine

JF - Journal of Experimental Medicine

IS - 4

M1 - e20220121

ER -

Allo-reactive tissue-resident T cells causing damage: An inside job

Abstract

Access to Document

Other files and links

Cite this