TY - JOUR
T1 - Altered Extracellular Matrix as an Alternative Risk Factor for Epileptogenicity in Brain Tumors
AU - de Jong, Jody M.
AU - Broekaart, Diede W. M.
AU - Bongaarts, Anika
AU - Mühlebner, Angelika
AU - Mills, James D.
AU - van Vliet, Erwin A.
AU - Aronica, Eleonora
N1 - Funding Information: This work has received funding from the European Union’s Horizon 2020 WIDESPREAD-05-2020–Twinning, EpiEpiNet, grant agreement no 952455 and KiKa, project number 208. Publisher Copyright: © 2022 by the authors.
PY - 2022/10/1
Y1 - 2022/10/1
N2 - Seizures are one of the most common symptoms of brain tumors. The incidence of seizures differs among brain tumor type, grade, location and size, but paediatric-type diffuse low-grade gliomas/glioneuronal tumors are often highly epileptogenic. The extracellular matrix (ECM) is known to play a role in epileptogenesis and tumorigenesis because it is involved in the (re)modelling of neuronal connections and cell-cell signaling. In this review, we discuss the epileptogenicity of brain tumors with a focus on tumor type, location, genetics and the role of the extracellular matrix. In addition to functional problems, epileptogenic tumors can lead to increased morbidity and mortality, stigmatization and life-long care. The health advantages can be major if the epileptogenic properties of brain tumors are better understood. Surgical resection is the most common treatment of epilepsy-associated tumors, but post-surgery seizure-freedom is not always achieved. Therefore, we also discuss potential novel therapies aiming to restore ECM function.
AB - Seizures are one of the most common symptoms of brain tumors. The incidence of seizures differs among brain tumor type, grade, location and size, but paediatric-type diffuse low-grade gliomas/glioneuronal tumors are often highly epileptogenic. The extracellular matrix (ECM) is known to play a role in epileptogenesis and tumorigenesis because it is involved in the (re)modelling of neuronal connections and cell-cell signaling. In this review, we discuss the epileptogenicity of brain tumors with a focus on tumor type, location, genetics and the role of the extracellular matrix. In addition to functional problems, epileptogenic tumors can lead to increased morbidity and mortality, stigmatization and life-long care. The health advantages can be major if the epileptogenic properties of brain tumors are better understood. Surgical resection is the most common treatment of epilepsy-associated tumors, but post-surgery seizure-freedom is not always achieved. Therefore, we also discuss potential novel therapies aiming to restore ECM function.
KW - brain tumor
KW - epileptogenesis
KW - extracellular matrix
KW - low-grade epilepsy-associated neuroepithelial tumors
KW - low-grade gliomas
KW - matrix metalloproteinases
UR - http://www.scopus.com/inward/record.url?scp=85140888868&partnerID=8YFLogxK
U2 - https://doi.org/10.3390/biomedicines10102475
DO - https://doi.org/10.3390/biomedicines10102475
M3 - Review article
C2 - 36289737
SN - 2227-9059
VL - 10
JO - Biomedicines
JF - Biomedicines
IS - 10
M1 - 2475
ER -