TY - JOUR
T1 - Amyloid PET and cognitive decline in cognitively normal individuals: the SCIENCe project
AU - Timmers, Tessa
AU - Ossenkoppele, Rik
AU - Verfaillie, Sander C. J.
AU - van der Weijden, Chris W. J.
AU - Slot, Rosalinde E. R.
AU - Wesselman, Linda M. P.
AU - Windhorst, Albert D.
AU - Wolters, Emma E.
AU - Yaqub, Maqsood
AU - Prins, Niels D.
AU - Lammertsma, Adriaan A.
AU - Scheltens, Philip
AU - van der Flier, Wiesje M.
AU - van Berckel, Bart N. M.
PY - 2019
Y1 - 2019
N2 - We examined the relationships between amyloid-β PET and concurrent and longitudinal cognitive performance in 107 cognitively normal individuals with subjective cognitive decline (age: 64 ± 8 years, 44% female, Mini-Mental State Examination score 29 ± 1). All underwent 90-minute dynamic [ 18 F]florbetapir PET scanning and longitudinal neuropsychological tests with a mean follow-up of 3.4 ± 3.0 years. Receptor parametric mapping was used to calculate [ 18 F]florbetapir binding potential (BP ND ), and we performed linear mixed models to assess the relationships between global [ 18 F]florbetapir BP ND and neuropsychological performance. Higher [ 18 F]florbetapir BP ND was related to lower concurrent Mini-Mental State Examination (β ± SE: −1.69 ± 0.63 p < 0.01) and to steeper rate of decline on tasks capturing memory (Rey Auditory Verbal Learning Task immediate [β ± SE −1.81 ± 0.81, p < 0.05] and delayed recall [β ± SE −1.19 ± 0.34, p < 0.01]), attention/executive functions (Stroop II [color] [β ± SE −0.02 ± 0.01, p < 0.05], Stroop III [word-color] [β ± SE −0.03 ± 0.02, p < 0.05]), and language (category fluency [β ± SE −0.04 ± 0.01, p < 0.01]). These findings suggest that higher amyloid-β load in cognitively normal individuals with subjective cognitive decline from a memory clinic is associated with lower concurrent global cognition and with faster rate of decline in a variety of cognitive domains.
AB - We examined the relationships between amyloid-β PET and concurrent and longitudinal cognitive performance in 107 cognitively normal individuals with subjective cognitive decline (age: 64 ± 8 years, 44% female, Mini-Mental State Examination score 29 ± 1). All underwent 90-minute dynamic [ 18 F]florbetapir PET scanning and longitudinal neuropsychological tests with a mean follow-up of 3.4 ± 3.0 years. Receptor parametric mapping was used to calculate [ 18 F]florbetapir binding potential (BP ND ), and we performed linear mixed models to assess the relationships between global [ 18 F]florbetapir BP ND and neuropsychological performance. Higher [ 18 F]florbetapir BP ND was related to lower concurrent Mini-Mental State Examination (β ± SE: −1.69 ± 0.63 p < 0.01) and to steeper rate of decline on tasks capturing memory (Rey Auditory Verbal Learning Task immediate [β ± SE −1.81 ± 0.81, p < 0.05] and delayed recall [β ± SE −1.19 ± 0.34, p < 0.01]), attention/executive functions (Stroop II [color] [β ± SE −0.02 ± 0.01, p < 0.05], Stroop III [word-color] [β ± SE −0.03 ± 0.02, p < 0.05]), and language (category fluency [β ± SE −0.04 ± 0.01, p < 0.01]). These findings suggest that higher amyloid-β load in cognitively normal individuals with subjective cognitive decline from a memory clinic is associated with lower concurrent global cognition and with faster rate of decline in a variety of cognitive domains.
KW - Amyloid-β
KW - Cognition
KW - Positron emission tomography (PET)
KW - Preclinical Alzheimer's disease
KW - Subjective cognitive decline (SCD)
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85064544165&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31026622
U2 - https://doi.org/10.1016/j.neurobiolaging.2019.02.020
DO - https://doi.org/10.1016/j.neurobiolaging.2019.02.020
M3 - Article
C2 - 31026622
SN - 0197-4580
VL - 79
SP - 50
EP - 58
JO - Neurobiology of aging
JF - Neurobiology of aging
ER -