An EEG signature of suicidal behavior in female patients with major depressive disorder? A non-replication

Noralie Krepel, Lars Benschop, Chris Baeken, Alexander T. Sack, Martijn Arns

Research output: Contribution to JournalReview articleAcademicpeer-review

2 Citations (Scopus)

Abstract

Introduction: A recent study showed hypoactivity in the beta/gamma band in female suicide ideators and suicide attempters diagnosed with depression, relative to a low-risk group. The current study aimed to conceptually replicate these results. Methods: In the iSPOT-D sub-sample (n = 402), suicide ideators and low-risk individuals were identified. Confining analyses to females only, differences between low-risk individuals and suicide ideators were tested for using the electroencephalogram (EEG) frequency bands SMR (Sensori-Motor-Rhythm; 12−15 Hz), beta (14.5−30 Hz), beta I (14.5−20 Hz), beta II (20−25 Hz), beta III (25−30 Hz), gamma I (31−49 Hz) using LORETA-software. Results: None of the tested frequency bands showed to be significantly different between suicide ideators and low-risk individuals. Conclusions: The current study could not conceptually replicate the earlier published results. Several reasons could explain this non-replication, among which possible electromyographic (EMG) contamination in the beta/gamma band in the original study. Trial Registration: ClinicalTrials.gov identifier: NCT00693849. URL: http://clinicaltrials.gov/ct2/show/NCT00693849.
Original languageEnglish
Article number108058
JournalBiological psychology
Volume161
DOIs
Publication statusPublished - 1 Apr 2021

Keywords

  • Electroencephalogram (EEG)
  • Replication
  • Suicide

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