AN INTEGRATED COMPUTER-AIDED APPROACH FOR MODELING DISINTEGRATION-RELATED PHENOMENA

C. CARAMELLA, F. FERRARI, M. RONCHI, A. K. Smilde

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Two phenomena have frequently been related to tablet disintegration: water uptake and disintegrating force development. The combination of these two measures allowed a step forward to understanding disintegration mechanisms. In the present work, multiple linear regression analysis was used to relate water penetration and force development to disintegration, taking into account as many formulation variables as possible. The experimental design envisaged three types of tablet formulations that were based on three base materials of differing solubility. Within each type of tablet formulations three disintegrants with differing swelling properties were employed in varying percentages to adjust the hydrophilicity of the formulation within a wide range. The disintegration time, water penetration and force development kinetics of the tablets were determined. Water penetration rate and force development rate were considered as predictive variables with regard to disintegration time which was considered as response variable. Different disintegrants and base materials were treated as "dummy" variables, which allowed to take into account the type of formulation. The overall results of the multiple linear regression analysis showed that the regression model for water penetration data is "per se" capable of elucidating the disintegration process. The regression model for disintegrating force data allows differentiation among various base materials and disintegrants
Original languageEnglish
Pages (from-to)249-253
JournalACTA PHARMACEUTICA TECHNOLOGICA-INTERNATIONAL JOURNAL OF DRUG FORUMLATION AND BIOPHARMACEUTICS
Volume36
Issue number4
Publication statusPublished - 1990

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