TY - JOUR
T1 - An integrative study of five biological clocks in somatic and mental health
AU - Jansen, Rick
AU - Han, Laura K.M.
AU - Verhoeven, Josine E.
AU - Aberg, Karolina A.
AU - van den Oord, Edwin C.G.J.
AU - Milaneschi, Yuri
AU - Penninx, Brenda W.J.H.
N1 - Funding Information: The infrastructure for the NESDA study (http://www.nesda.nl) is funded through the Geestkracht program of the Netherlands Organisation for Health Research and Development (ZonMw, grant number 10-000-1002) and financial contributions by participating universities and mental health care organizations (VU University Medical Center, GGZ inGeest, Leiden University Medical Center, Leiden University, GGZ Rivierduinen, University Medical Center Groningen, University of Groningen, Lentis, GGZ Friesland, GGZ Drenthe, Rob Giel Onderzoekscentrum). Telomere length assaying was supported through a NWO-VICI grant (number 91811602). Methylation sequencing was supported by NIMH grant R01MH099110. Metabolomics data were generated within the framework of the BBMRI Metabolomics Consortium funded by BBMRI-NL, a research infrastructure financed by the Dutch government (NWO, grant nr 184.021.007 and 184033111). Gene expression data were funded by the US National Institute of Mental Health (RC2MH089951). Publisher Copyright: © Jansen et al. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/2
Y1 - 2021/2
N2 - Biological clocks have been developed at different molecular levels and were found to be more advanced in the presence of somatic illness and mental disorders. However, it is unclear whether different biological clocks reflect similar aging processes and determinants. In ~3000 subjects, we examined whether five biological clocks (telomere length, epigenetic, transcriptomic, proteomic, and metabolomic clocks) were interrelated and associated to somatic and mental health determinants. Correlations between biological aging indicators were small (all r < 0.2), indicating little overlap. The most consistent associations of advanced biological aging were found for male sex, higher body mass index (BMI), metabolic syndrome, smoking, and depression. As compared to the individual clocks, a composite index of all five clocks showed most pronounced associations with health determinants. The large effect sizes of the composite index and the low correlation between biological aging indicators suggest that one’s biological age is best reflected by combining aging measures from multiple cellular levels.
AB - Biological clocks have been developed at different molecular levels and were found to be more advanced in the presence of somatic illness and mental disorders. However, it is unclear whether different biological clocks reflect similar aging processes and determinants. In ~3000 subjects, we examined whether five biological clocks (telomere length, epigenetic, transcriptomic, proteomic, and metabolomic clocks) were interrelated and associated to somatic and mental health determinants. Correlations between biological aging indicators were small (all r < 0.2), indicating little overlap. The most consistent associations of advanced biological aging were found for male sex, higher body mass index (BMI), metabolic syndrome, smoking, and depression. As compared to the individual clocks, a composite index of all five clocks showed most pronounced associations with health determinants. The large effect sizes of the composite index and the low correlation between biological aging indicators suggest that one’s biological age is best reflected by combining aging measures from multiple cellular levels.
UR - http://www.scopus.com/inward/record.url?scp=85101267948&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85101267948&partnerID=8YFLogxK
U2 - https://doi.org/10.7554/eLife.59479
DO - https://doi.org/10.7554/eLife.59479
M3 - Article
C2 - 33558008
SN - 2050-084X
VL - 10
SP - 1
EP - 20
JO - eLife
JF - eLife
M1 - e59479
ER -