Anal squamous intraepithelial lesions in HIV+ MSM

M.L. Siegenbeek van Heukelom

Anal squamous intraepithelial lesions in HIV+ MSM

Doctoral School

Research output: PhD Thesis › Phd-Thesis - Research and graduation internal

Abstract

In this thesis we report on several aspects of high-grade anal squamous intraepithelial lesions (HSIL) in HIV+ men who have sex with men (MSM). It is estimated that 10% of HIV+ MSM with anal HSIL will develop anal squamous cell carcinoma (ASCC) over 30 years time. Screening programs similar to cervical cancer screening focus on identification and treatment of anal HSIL. However, if ASCC can be prevented is still subject of debate. We report on risk factors for anal HSIL, causative HPV-types of intra-anal condylomatous lesions, the learning curve for high-resolution anoscopists identifying HSIL, the impact of anal HSIL treatments (electrocoagulation, imiquimod creme and efudix creme) on quality of life and sex life of HIV+ MSM and on cryotherapy as a potential new treatment for anal HSIL.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution
Supervisors/Advisors	Prins, Jan Marinus, Supervisor de Vries, Henry, Supervisor Richel, O., Co-supervisor Schim van der Loeff, M.F., Co-supervisor
Award date	13 Jun 2018
Print ISBNs	9789463323529
Publication status	Published - 2018

Access to Document

Cite this

@phdthesis{d784791dc6e44ac8a17eec8e71601559,

title = "Anal squamous intraepithelial lesions in HIV+ MSM",

abstract = "In this thesis we report on several aspects of high-grade anal squamous intraepithelial lesions (HSIL) in HIV+ men who have sex with men (MSM). It is estimated that 10% of HIV+ MSM with anal HSIL will develop anal squamous cell carcinoma (ASCC) over 30 years time. Screening programs similar to cervical cancer screening focus on identification and treatment of anal HSIL. However, if ASCC can be prevented is still subject of debate. We report on risk factors for anal HSIL, causative HPV-types of intra-anal condylomatous lesions, the learning curve for high-resolution anoscopists identifying HSIL, the impact of anal HSIL treatments (electrocoagulation, imiquimod creme and efudix creme) on quality of life and sex life of HIV+ MSM and on cryotherapy as a potential new treatment for anal HSIL.",

author = "{Siegenbeek van Heukelom}, M.L.",

year = "2018",

language = "English",

isbn = "9789463323529",

type = "Phd-Thesis - Research and graduation internal",

}

TY - THES

T1 - Anal squamous intraepithelial lesions in HIV+ MSM

AU - Siegenbeek van Heukelom, M.L.

PY - 2018

Y1 - 2018

N2 - In this thesis we report on several aspects of high-grade anal squamous intraepithelial lesions (HSIL) in HIV+ men who have sex with men (MSM). It is estimated that 10% of HIV+ MSM with anal HSIL will develop anal squamous cell carcinoma (ASCC) over 30 years time. Screening programs similar to cervical cancer screening focus on identification and treatment of anal HSIL. However, if ASCC can be prevented is still subject of debate. We report on risk factors for anal HSIL, causative HPV-types of intra-anal condylomatous lesions, the learning curve for high-resolution anoscopists identifying HSIL, the impact of anal HSIL treatments (electrocoagulation, imiquimod creme and efudix creme) on quality of life and sex life of HIV+ MSM and on cryotherapy as a potential new treatment for anal HSIL.

AB - In this thesis we report on several aspects of high-grade anal squamous intraepithelial lesions (HSIL) in HIV+ men who have sex with men (MSM). It is estimated that 10% of HIV+ MSM with anal HSIL will develop anal squamous cell carcinoma (ASCC) over 30 years time. Screening programs similar to cervical cancer screening focus on identification and treatment of anal HSIL. However, if ASCC can be prevented is still subject of debate. We report on risk factors for anal HSIL, causative HPV-types of intra-anal condylomatous lesions, the learning curve for high-resolution anoscopists identifying HSIL, the impact of anal HSIL treatments (electrocoagulation, imiquimod creme and efudix creme) on quality of life and sex life of HIV+ MSM and on cryotherapy as a potential new treatment for anal HSIL.

UR - https://pure.uva.nl/ws/files/25040436/Licentieovereenkomst_medeondertekend_.pdf

M3 - Phd-Thesis - Research and graduation internal

SN - 9789463323529

ER -

Anal squamous intraepithelial lesions in HIV+ MSM

Abstract

Access to Document

Other files and links

Cite this