TY - JOUR
T1 - Analysis of clinical data to determine the minimum number of sensors required for adequate skin temperature monitoring of superficial hyperthermia treatments
AU - Bakker, Akke
AU - Holman, Rebecca
AU - Rodrigues, Dario B.
AU - Dobšíček Trefná, Hana
AU - Stauffer, Paul R.
AU - van Tienhoven, Geertjan
AU - Rasch, Coen R. N.
AU - Crezee, Hans
PY - 2018
Y1 - 2018
N2 - Purpose: Tumor response and treatment toxicity are related to minimum and maximum tissue temperatures during hyperthermia, respectively. Using a large set of clinical data, we analyzed the number of sensors required to adequately monitor skin temperature during superficial hyperthermia treatment of breast cancer patients. Methods: Hyperthermia treatments monitored with >60 stationary temperature sensors were selected from a database of patients with recurrent breast cancer treated with re-irradiation (23 × 2 Gy) and hyperthermia using single 434 MHz applicators (effective field size 351–396 cm 2 ). Reduced temperature monitoring schemes involved randomly selected subsets of stationary skin sensors, and another subset simulating continuous thermal mapping of the skin. Temperature differences (ΔT) between subsets and complete sets of sensors were evaluated in terms of overall minimum (T min ) and maximum (T max ) temperature, as well as T90 and T10. Results: Eighty patients were included yielding a total of 400 hyperthermia sessions. Median ΔT was <0.01 °C for T90, its 95% confidence interval (95%CI) decreased to ≤0.5 °C when >50 sensors were used. Subsets of <10 sensors result in underestimation of T max up to −2.1 °C (ΔT 95%CI), which decreased to −0.5 °C when >50 sensors were used. Thermal profiles (8–21 probes) yielded a median ΔT < 0.01 °C for T90 and T max , with a 95%CI of −0.2 °C and 0.4 °C, respectively. The detection rate of T max ≥43 °C is ≥85% while using >50 stationary sensors or thermal profiles. Conclusions: Adequate coverage of the skin temperature distribution during superficial hyperthermia treatment requires the use of >50 stationary sensors per 400 cm 2 applicator. Thermal mapping is a valid alternative.
AB - Purpose: Tumor response and treatment toxicity are related to minimum and maximum tissue temperatures during hyperthermia, respectively. Using a large set of clinical data, we analyzed the number of sensors required to adequately monitor skin temperature during superficial hyperthermia treatment of breast cancer patients. Methods: Hyperthermia treatments monitored with >60 stationary temperature sensors were selected from a database of patients with recurrent breast cancer treated with re-irradiation (23 × 2 Gy) and hyperthermia using single 434 MHz applicators (effective field size 351–396 cm 2 ). Reduced temperature monitoring schemes involved randomly selected subsets of stationary skin sensors, and another subset simulating continuous thermal mapping of the skin. Temperature differences (ΔT) between subsets and complete sets of sensors were evaluated in terms of overall minimum (T min ) and maximum (T max ) temperature, as well as T90 and T10. Results: Eighty patients were included yielding a total of 400 hyperthermia sessions. Median ΔT was <0.01 °C for T90, its 95% confidence interval (95%CI) decreased to ≤0.5 °C when >50 sensors were used. Subsets of <10 sensors result in underestimation of T max up to −2.1 °C (ΔT 95%CI), which decreased to −0.5 °C when >50 sensors were used. Thermal profiles (8–21 probes) yielded a median ΔT < 0.01 °C for T90 and T max , with a 95%CI of −0.2 °C and 0.4 °C, respectively. The detection rate of T max ≥43 °C is ≥85% while using >50 stationary sensors or thermal profiles. Conclusions: Adequate coverage of the skin temperature distribution during superficial hyperthermia treatment requires the use of >50 stationary sensors per 400 cm 2 applicator. Thermal mapping is a valid alternative.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85046010936&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29658357
U2 - https://doi.org/10.1080/02656736.2018.1466000
DO - https://doi.org/10.1080/02656736.2018.1466000
M3 - Article
C2 - 29658357
SN - 0265-6736
VL - 34
SP - 910
EP - 917
JO - International journal of hyperthermia
JF - International journal of hyperthermia
IS - 7
ER -