TY - JOUR
T1 - Anatomy, Function, and Dysfunction of the Right Ventricle
T2 - JACC State-of-the-Art Review
AU - Sanz, Javier
AU - Sánchez-Quintana, Damián
AU - Bossone, Eduardo
AU - Bogaard, Harm J.
AU - Naeije, Robert
N1 - Copyright © 2019 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
PY - 2019
Y1 - 2019
N2 - There is increasing recognition of the crucial role of the right ventricle (RV) in determining functional status and prognosis in multiple conditions. The normal RV is anatomically and functionally different from the left ventricle, which precludes direct extrapolation of our knowledge of left-sided physiopathology to the right heart. RV adaptation is largely determined by the level of exposure to hemodynamic overload (both preload and afterload) as well as its intrinsic contractile function. These 3 processes (pressure overload, volume overload, and RV cardiomyopathy) are associated with distinct clinical course and therapeutic approach, although in reality they often coexist in various degrees. The close relationship between the RV and left ventricle (ventricular interdependence) and its coupling to the pulmonary circulation further modulate RV behavior in different clinical scenarios. In this review, the authors summarize current knowledge of RV anatomic, structural, metabolic, functional, and hemodynamic characteristics in both health and disease.
AB - There is increasing recognition of the crucial role of the right ventricle (RV) in determining functional status and prognosis in multiple conditions. The normal RV is anatomically and functionally different from the left ventricle, which precludes direct extrapolation of our knowledge of left-sided physiopathology to the right heart. RV adaptation is largely determined by the level of exposure to hemodynamic overload (both preload and afterload) as well as its intrinsic contractile function. These 3 processes (pressure overload, volume overload, and RV cardiomyopathy) are associated with distinct clinical course and therapeutic approach, although in reality they often coexist in various degrees. The close relationship between the RV and left ventricle (ventricular interdependence) and its coupling to the pulmonary circulation further modulate RV behavior in different clinical scenarios. In this review, the authors summarize current knowledge of RV anatomic, structural, metabolic, functional, and hemodynamic characteristics in both health and disease.
KW - pulmonary hypertension
KW - right ventricle
KW - right ventricular function
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85062965923&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30922478
U2 - https://doi.org/10.1016/j.jacc.2018.12.076
DO - https://doi.org/10.1016/j.jacc.2018.12.076
M3 - Review article
C2 - 30922478
SN - 0735-1097
VL - 73
SP - 1463
EP - 1482
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 12
ER -