TY - JOUR
T1 - Animal models for cystic fibrosis
T2 - a systematic search and mapping review of the literature. Part 2: nongenetic models
AU - Leenaars, Cathalijn H. C.
AU - Vries, Rob B. M. de
AU - Reijmer, Joey
AU - Holthaus, David
AU - Visser, Damian
AU - Heming, Anna
AU - Elzinga, Janneke
AU - Kempkes, Rosalie W. M.
AU - Beumer, Wouter
AU - Punt, Carine
AU - Meijboom, Franck L. B.
AU - Ritskes-Hoitinga, Merel
N1 - Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by NWO [grant number 313-99-310], R2N, Federal State of Lower Saxony, and the DFG [grant number FOR2591, BL 953/11-2]. Funding Information: The authors would like to acknowledge Alice Tillema (information specialist) and Peter Mercus (clinician) for reviewing our protocol. The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by NWO [grant number 313-99-310], R2N, Federal State of Lower Saxony, and the DFG [grant number FOR2591, BL 953/11-2]. Publisher Copyright: © The Author(s) 2021. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/8
Y1 - 2021/8
N2 - Various animal models are available to study cystic fibrosis (CF). These models may help to enhance our understanding of the pathology and contribute to the development of new treatments. We systematically searched all publications on CF animal models. Because of the large number of models retrieved, we split this mapping review into two parts. Previously, we presented the genetic CF animal models. In this paper we present the nongenetic CF animal models. While genetic animal models may, in theory, be preferable for genetic diseases, the phenotype of a genetic model does not automatically resemble human disease. Depending on the research question, other animal models may thus be more informative. We searched Pubmed and Embase and identified 12,303 unique publications (after duplicate removal). All references were screened for inclusion by two independent reviewers. The genetic animal models for CF (from 636 publications) were previously described. The non-genetic CF models (from 189 publications) are described in this paper, grouped by model type: infection-based, pharmacological, administration of human materials, xenografts and other. As before for the genetic models, an overview of basic model characteristics and outcome measures is provided. This CF animal model overview can be the basis for an objective, evidence-based model choice for specific research questions. Besides, it can help to retrieve relevant background literature on outcome measures of interest.
AB - Various animal models are available to study cystic fibrosis (CF). These models may help to enhance our understanding of the pathology and contribute to the development of new treatments. We systematically searched all publications on CF animal models. Because of the large number of models retrieved, we split this mapping review into two parts. Previously, we presented the genetic CF animal models. In this paper we present the nongenetic CF animal models. While genetic animal models may, in theory, be preferable for genetic diseases, the phenotype of a genetic model does not automatically resemble human disease. Depending on the research question, other animal models may thus be more informative. We searched Pubmed and Embase and identified 12,303 unique publications (after duplicate removal). All references were screened for inclusion by two independent reviewers. The genetic animal models for CF (from 636 publications) were previously described. The non-genetic CF models (from 189 publications) are described in this paper, grouped by model type: infection-based, pharmacological, administration of human materials, xenografts and other. As before for the genetic models, an overview of basic model characteristics and outcome measures is provided. This CF animal model overview can be the basis for an objective, evidence-based model choice for specific research questions. Besides, it can help to retrieve relevant background literature on outcome measures of interest.
KW - Animal models
KW - cystic fibrosis
KW - outcome measures
KW - search string
KW - systematic map
UR - http://www.scopus.com/inward/record.url?scp=85101001825&partnerID=8YFLogxK
U2 - https://doi.org/10.1177/0023677221990688
DO - https://doi.org/10.1177/0023677221990688
M3 - Review article
C2 - 33557683
SN - 0023-6772
VL - 55
SP - 307
EP - 316
JO - LABORATORY ANIMALS
JF - LABORATORY ANIMALS
IS - 4
ER -