Animal models of human respiratory syncytial virus disease

Reinout A. Bem, Joseph B. Domachowske, Helene F. Rosenberg

Research output: Contribution to journalReview articleAcademicpeer-review

150 Citations (Scopus)


Infection with the human pneumovirus pathogen, respiratory syncytial virus (hRSV), causes a wide spectrum of respiratory disease, notably among infants and the elderly. Laboratory animal studies permit detailed experimental modeling of hRSV disease and are therefore indispensable in the search for novel therapies and preventative strategies. Present animal models include several target species for hRSV, including chimpanzees, cattle, sheep, cotton rats, and mice, as well as alternative animal pneumovirus models, such as bovine RSV and pneumonia virus of mice. These diverse animal models reproduce different features of hRSV disease, and their utilization should therefore be based on the scientific hypothesis under investigation. The purpose of this review is to summarize the strengths and limitations of each of these animal models. Our intent is to provide a resource for investigators and an impetus for future research
Original languageEnglish
Pages (from-to)L148-L156
JournalAmerican journal of physiology. Lung cellular and molecular physiology
Issue number2
Publication statusPublished - 2011

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